Vitamin D status and associations with substance use patterns among people with severe substance use disorders in Western Norway.

Autor: Bemanian M; Bergen Addiction Research, Department of Addiction Medicine, Haukeland University Hospital, Post Box 1400, 5021, Bergen, Norway. jig002@uib.no.; Department of Global Public Health and Primary Care, Faculty of Medicine, University of Bergen, Bergen, Norway. jig002@uib.no., Chowdhury R; Centre for Health Research and Development, Society for Applied Studies, New Delhi, India., Stokke K; Bergen Addiction Research, Department of Addiction Medicine, Haukeland University Hospital, Post Box 1400, 5021, Bergen, Norway.; Department of Global Public Health and Primary Care, Faculty of Medicine, University of Bergen, Bergen, Norway., Aas CF; Bergen Addiction Research, Department of Addiction Medicine, Haukeland University Hospital, Post Box 1400, 5021, Bergen, Norway.; Department of Global Public Health and Primary Care, Faculty of Medicine, University of Bergen, Bergen, Norway.; Division of Psychiatry, Haukeland University Hospital, Bergen, Norway., Johansson KA; Bergen Addiction Research, Department of Addiction Medicine, Haukeland University Hospital, Post Box 1400, 5021, Bergen, Norway.; Department of Global Public Health and Primary Care, Faculty of Medicine, University of Bergen, Bergen, Norway., Vold JH; Bergen Addiction Research, Department of Addiction Medicine, Haukeland University Hospital, Post Box 1400, 5021, Bergen, Norway.; Department of Global Public Health and Primary Care, Faculty of Medicine, University of Bergen, Bergen, Norway.; Division of Psychiatry, Haukeland University Hospital, Bergen, Norway., Fadnes LT; Bergen Addiction Research, Department of Addiction Medicine, Haukeland University Hospital, Post Box 1400, 5021, Bergen, Norway.; Department of Global Public Health and Primary Care, Faculty of Medicine, University of Bergen, Bergen, Norway.
Jazyk: angličtina
Zdroj: Scientific reports [Sci Rep] 2022 Aug 11; Vol. 12 (1), pp. 13695. Date of Electronic Publication: 2022 Aug 11.
DOI: 10.1038/s41598-022-17804-w
Abstrakt: Chronic and harmful substance use is associated with a cluster of harms to health, including micronutrient deficiencies. Maintaining adequate levels of vitamin D is important for musculoskeletal and other aspects of health. In this prospective longitudinal cohort study, 666 participants drawn from outpatient opioid agonist therapy (OAT) clinics and community care clinics for substance use disorder in Western Norway were assessed annually for determination of serum 25-hydroxyvitamin D [s-25(OH)D] levels. Fifty-seven percent were deficient at baseline (s-25(OH)D < 50 nmol/l), and 19% were severely deficient (s-25(OH)D < 25 nmol/l). Among those deficient/severely deficient at baseline, 70% remained deficient/severely deficient at the last measurement (mean duration 714 days). Substance use patterns and dosage of opioids for OAT were not associated with vitamin D levels. One exception was found for cannabis, where consumption on a minimum weekly basis was associated with lower levels at baseline (mean difference: -5.2 nmol/l, 95% confidence interval [CI]: -9.1, - 1.3), but without clear time trends (mean change per year: 1.4 nmol/l, CI: - 0.86, 3.7). The high prevalence of sustained vitamin D deficiency in this cohort highlights the need for targeted monitoring and supplementation for this and similar at-risk populations.
(© 2022. The Author(s).)
Databáze: MEDLINE
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