Pretreatment electroencephalographic features in patients with childhood absence epilepsy.

Autor: Özçelik EU; Istanbul University, Cerrahpaşa School of Medicine, Departments of Neurology and Childhood Neurology, Istanbul, Türkiye; Istanbul Health and Technology University, Faculty of Health Sciences, Department of Ergotherapy, Istanbul, Türkiye. Electronic address: emeluscas@gmail.com., Çokar Ö; University of Health Sciences, Hamidiye School of Medicine, Haseki Educational and Research Hospital, Department of Neurology, Istanbul, Türkiye., Demirbilek V; Istanbul University, Cerrahpaşa School of Medicine, Departments of Neurology and Childhood Neurology, Istanbul, Türkiye.
Jazyk: angličtina
Zdroj: Neurophysiologie clinique = Clinical neurophysiology [Neurophysiol Clin] 2022 Aug; Vol. 52 (4), pp. 280-289. Date of Electronic Publication: 2022 Aug 08.
DOI: 10.1016/j.neucli.2022.07.003
Abstrakt: Objective: To analyze the ictal and interictal electroencephalographic (EEG) features in newly diagnosed childhood absence epilepsy (CAE) and determine the association between seizure onset topography, interictal focal spike-wave discharges (FSWDs) and accompanying clinical features of absence seizures.
Methods: The authors searched the EEG database for a definite diagnosis of CAE according to ILAE 2017 criteria. Video-EEGs of untreated pediatric patients during sleep and wakefulness were evaluated retrospectively.
Results: The study included 47 patients (25 males, 22 females). Interictal FSWDs were observed in 49% of patients with CAE during wakefulness and in 85.1% during sleep (p = 0.001). Interictal FSWDs were most frequently observed in the frontal regions (awake: 34%; asleep: 74.5%), followed by the posterior temporoparietooccipital region (awake: 21.2%; asleep: 36.1%), and the centrotemporal region (awake: 6.4%; asleep: 8.5%). Eleven patients (23.4%) had polyspikes during sleep. Both bilateral symmetric and asymmetric seizure onset were noted in 32%, whereas focal seizure onset was observed in 14.9% of the patients. Absence seizures with and without motor components were seen in 72.3% and 61.7% of patients, respectively, and in 33% of patients both occurred. There were no associations between the existence of interictal FSWDs, focal/asymmetric seizure onset, and absence seizures with and/or without motor components.
Conclusion: Asymmetric and/or focal seizure onset, interictal FSWDs, and absence seizures with motor components are commonly observed in drug-naive CAE. This study found no association between seizure onset topography, interictal FSWDs, and semiological features of absence seizures.
Competing Interests: Conflicts of Interest Statement The authors declare there are no conflicts of interest—financial or otherwise—related to the material presented herein.
(Copyright © 2022 Elsevier Masson SAS. All rights reserved.)
Databáze: MEDLINE
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