Inter-method reliability of silicone exposome wristbands and urinary biomarker assays in a pregnancy cohort.

Autor: Romano ME; Department of Epidemiology, Geisel School of Medicine, Dartmouth College, Hanover, NH, USA. Electronic address: megan.e.romano@dartmouth.edu., Gallagher L; Department of Epidemiology, Geisel School of Medicine, Dartmouth College, Hanover, NH, USA., Doherty BT; Department of Epidemiology, Geisel School of Medicine, Dartmouth College, Hanover, NH, USA., Yeum D; Department of Epidemiology, Geisel School of Medicine, Dartmouth College, Hanover, NH, USA., Lee S; Department of Pediatrics and Department of Environmental Medicine, New York University Grossman School of Medicine, New York, NY, USA., Takazawa M; Department of Pediatrics and Department of Environmental Medicine, New York University Grossman School of Medicine, New York, NY, USA., Anderson KA; Department of Environmental and Molecular Toxicology, Oregon State University, Corvallis, OR, USA. States., Kannan K; Department of Pediatrics and Department of Environmental Medicine, New York University Grossman School of Medicine, New York, NY, USA., Karagas MR; Department of Epidemiology, Geisel School of Medicine, Dartmouth College, Hanover, NH, USA.
Jazyk: angličtina
Zdroj: Environmental research [Environ Res] 2022 Nov; Vol. 214 (Pt 3), pp. 113981. Date of Electronic Publication: 2022 Aug 08.
DOI: 10.1016/j.envres.2022.113981
Abstrakt: Silicone wristbands act as passive environmental samplers capable of detecting and measuring concentrations of a variety of chemicals. They offer a noninvasive method to collect complex exposure data in large-scale epidemiological studies. We evaluated the inter-method reliability of silicone wristbands and urinary biomarkers in the New Hampshire Birth Cohort Study. A subset of study participants (n = 96) provided a urine sample and wore a silicone wristband for 7 days at approximately 12 gestational weeks. Women were instructed to wear the wristbands during all their normal activities. Concentrations of urinary compounds and metabolites in the urine and parent compounds in wristbands were compared. High detection rates were observed for triphenyl phosphate (76.0%) and benzophenone (78.1%) in wristbands, although the distribution of corresponding urinary concentrations of chemicals did not differ according to whether chemicals were detected or not detected in wristbands. While detected among only 8.3% of wristbands, median urinary triclosan concentrations were higher among those with triclosan detected in wristbands (9.04 ng/mL) than without (0.16 ng/mL). For most chemicals slight to fair agreement was observed across exposure assessment methods, potentially due to low rates of detection in the wristbands for chemicals where observed urinary concentrations were relatively low as compared to background concentrations in the general population. Our findings support the growing body of research in support of deploying silicone wristbands as an important exposure assessment tool.
Competing Interests: Declaration of competing interest The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: Kim Anderson, an author of this research, discloses a financial interest in MyExposome, Inc., which is marketing products related to the research being reported. The terms of this arrangement have been reviewed and approved by OSU in accordance with its policy on research conflicts of interest.
(Copyright © 2022 Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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