Post-COVID-19 outcomes of non-dialysis dependent chronic kidney disease patients: a national, multicenter, controlled study.

Autor: Karadag S; Department of Nephrology, University of Health Sciences, Haseki Training and Research Hospital, Istanbul, Turkey., Ozturk S; Istanbul Faculty of Medicine, Department of Internal Medicine, Division of Nephrology, Istanbul University, Istanbul, Turkey., Arici M; Faculty of Medicine, Department of Internal Medicine, Division of Nephrology, Hacettepe University, Ankara, Turkey. marici@hacettepe.edu.tr., Gorgulu N; Department of Nephrology, University of Health Sciences, Bagcilar Training and Research Hospital, Istanbul, Turkey., Akcali E; Faculty of Medicine, Department of Internal Medicine, Division of Nephrology, Mersin University, Mersin, Turkey., Pembegul I; Faculty of Medicine, Department of Internal Medicine, Division of Nephrology, Malatya Turgut Ozal University, Malatya, Turkey., Taymez DG; Department of Nephrology, Kocaeli State Hospital, Kocaeli, Turkey., Kazancioglu R; Faculty of Medicine, Department of Internal Medicine, Division of Nephrology, Bezmialem Vakif University, Istanbul, Turkey., Ayar Y; Faculty of Medicine, Department of Nephrology, University of Health Sciences, Bursa City Hospital, Bursa, Turkey., Mutluay R; Department of Internal Medicine, Division of Nephrology, Faculty of Medicine Eskisehir Osmangazi University, Eskişehir, Turkey., Ozdemir A; Department of Nephrology, University of Health Sciences, Bakirkoy Doctor Sadi Konuk Training and Research Hospital, Istanbul, Turkey., Aydin Z; Department of Nephrology, University of Health Sciences, Darica Farabi Training and Research Hospital, Kocaeli, Turkey., Bashan Y; Department of Nephrology, University of Health Sciences, Haseki Training and Research Hospital, Istanbul, Turkey., Alagoz S; Department of Nephrology, University of Health Sciences, Istanbul Training and Research Hospital, Istanbul, Turkey., Yilmaz F; Department of Nephrology, Antalya Atatürk State Hospital, Antalya, Turkey., Trabulus S; Cerrahpasa Medical Faculty, Department of Internal Medicine, Division of Nephrology, Istanbul University-Cerrahpasa, Istanbul, Turkey., Dirim AB; Istanbul Faculty of Medicine, Department of Internal Medicine, Division of Nephrology, Istanbul University, Istanbul, Turkey., Ozturk I; Faculty of Medicine, Department of Internal Medicine, Division of Nephrology, Sutcu Imam University, Kahramanmaras, Turkey., Inci A; Department of Nephrology, University of Health Sciences, Antalya Training and Research Hospital, Antalya, Turkey., Azak A; Department of Nephrology, Balikesir Atatürk Education and Research Hospital, Balikesir, Turkey., Aktas N; Department of Nephrology, University of Health Sciences, Bursa Yüksek Ihtisas Training and Research Hospital, Bursa, Turkey., Kuzu T; Faculty of Medicine, Department of Internal Medicine, Division of Nephrology, Cukurova University, Adana, Turkey., Dheir H; Sakarya Faculty of Medicine, Department of Internal Medicine, Division of Nephrology, Sakarya University, Sakarya, Turkey., Basturk T; Department of Nephrology, University of Health Sciences, Sisli Hamidıye Etfal Training and Research Hospital, Istanbul, Turkey., Ozler TE; Faculty of Medicine, Department of Internal Medicine, Division of Nephrology, Amasya University, Amasya, Turkey., Dincer MT; Department of Nephrology, University of Health Sciences, Bagcilar Training and Research Hospital, Istanbul, Turkey., Turgutalp K; Faculty of Medicine, Department of Internal Medicine, Division of Nephrology, Mersin University, Mersin, Turkey., Ulu S; Faculty of Medicine, Department of Internal Medicine, Division of Nephrology, Bahcesehir University, Istanbul, Turkey., Gungor O; Faculty of Medicine, Department of Internal Medicine, Division of Nephrology, Sutcu Imam University, Kahramanmaras, Turkey., Bakir EA; Department of Nephrology, University of Health Sciences, Kartal Dr.Lutfi Kirdar Training and Research Hospital, Istanbul, Turkey., Odabas AR; Department of Nephrology, University of Health Sciences, Istanbul Sultan Abdulhamid Han Training and Research Hospital, Istanbul, Turkey., Seyahi N; Cerrahpasa Medical Faculty, Department of Internal Medicine, Division of Nephrology, Istanbul University-Cerrahpasa, Istanbul, Turkey., Yildiz A; Istanbul Faculty of Medicine, Department of Internal Medicine, Division of Nephrology, Istanbul University, Istanbul, Turkey., Ates K; Faculty of Medicine, Department of Internal Medicine, Division of Nephrology, Ankara University, Ankara, Turkey.
Jazyk: angličtina
Zdroj: International urology and nephrology [Int Urol Nephrol] 2023 Feb; Vol. 55 (2), pp. 399-408. Date of Electronic Publication: 2022 Aug 11.
DOI: 10.1007/s11255-022-03329-8
Abstrakt: Purpose: Coronavirus disease 2019 (COVID-19) has a higher mortality in the presence of chronic kidney disease (CKD). However, there has not been much research in the literature concerning the outcomes of CKD patients in the post-COVID-19 period. We aimed to investigate the outcomes of CKD patients not receiving renal replacement therapy.
Methods: In this multicenter observational study, we included CKD patients with a GFR < 60 ml/min/1.73 m 2 who survived after confirmed COVID-19. Patients with CKD whose kidney disease was due to diabetic nephropathy, polycystic kidney disease and glomerulonephritis were not included in this study. CKD patients with similar characteristics, who did not have COVID-19 were included as the control group.
Results: There were 173 patients in the COVID-19 group and 207 patients in the control group. Most patients (72.8%) were treated as inpatient in the COVID-19 group (intensive care unit hospitalization: 16.7%, acute kidney injury: 54.8%, needing dialysis: 7.9%). While there was no significant difference between the baseline creatinine values of the COVID-19 group and the control group (1.86 and 1.9, p = 0.978, respectively), on the 1st month, creatinine values were significantly higher in the COVID-19 group (2.09 and 1.8, respectively, p = 0.028). Respiratory system symptoms were more common in COVID-19 patients compared to the control group in the 1st month and 3rd month follow-ups (p < 0.001). Mortality at 3 months after the diagnosis of COVID-19 was significantly higher in the COVID-19 group than in the control group (respectively; 5.2% and 1.4%, p:0.037). Similarly, the rate of patients requiring dialysis for COVID-19 was significantly higher than the control group (respectively; 8.1% and 3.4%, p: 0.045).
Conclusions: In CKD patients, COVID-19 was associated with increased mortality, as well as more deterioration in kidney function and higher need for dialysis in the post-COVID-19 period. These patients also had higher rate of ongoing respiratory symptoms after COVID-19.
(© 2022. The Author(s), under exclusive licence to Springer Nature B.V.)
Databáze: MEDLINE
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