Predictive Significance of Tumour Size in Patients Undergoing Curative Surgery for Colorectal Cancer: A Retrospective Cohort Study.

Autor:	Hajibandeh S; Department of General Surgery, Wrexham Maelor Hospital, Betsi Cadwaladr University Health Board, Wrexham, GBR., Barghash M; Department of General Surgery, North Manchester General Hospital, Manchester University NHS Foundation Trust, Manchester, GBR., Khan RMA; Department of General and Colorectal Surgery, The Royal Oldham Hospital, Northern Care Alliance, Oldham, GBR., Milgrom D; Department of Vascular Surgery, Royal Preston Hospital, Lancashire Teaching Hospitals NHS Foundation Trust, Preston, GBR., Ali S; Department of General Surgery, North Manchester General Hospital, Manchester University NHS Foundation Trust, Manchester, GBR., Ali S; Bowel Cancer Screening, Harrogate and District NHS Foundation Trust, Harrogate, GBR., Ali B; Department of General and Colorectal Surgery, The Royal Oldham Hospital, Northern Care Alliance, Oldham, GBR.
Jazyk:	angličtina
Zdroj:	Cureus [Cureus] 2022 Jul 08; Vol. 14 (7), pp. e26656. Date of Electronic Publication: 2022 Jul 08 (Print Publication: 2022).
DOI:	10.7759/cureus.26656
Abstrakt:	Objectives To evaluate the predictive significance of tumour size in patients undergoing curative surgery for colorectal cancer (CRC). Methods All patients undergoing curative surgery for colon or rectum cancer performed by a single colorectal surgeon between January 2013 and January 2020 were considered eligible for inclusion. Linear and binary logistic regression analyses were modelled to assess whether colonic or rectal tumour size could predict R0 resection, specimen length, number of harvested and positive lymph nodes, lymphocytic infiltration, venous invasion, and overall survival. Results A total of 192 patients were eligible for inclusion. In patients with colon cancer, tumour size was the independent predictor of the number of harvested lymph nodes (P<0.001), the number of positive lymph nodes (P=0.001), and lymphocytic infiltration (P=0.009). However, it did not predict R0 resection (P=0.563), specimen length (P=0.111), specimen length >120 mm (P=0.186), >12 harvested lymph nodes (P=0.145), venous invasion (P=0.103), and five-year overall survival (P=0.543). In patients with rectal cancer, tumour size was the independent predictor of the number of harvested lymph nodes (P<0.001) and the number of positive lymph nodes (P<0.001). However, it did not predict R0 resection (P=0.108), specimen length (P=0.774), specimen length >120 mm (P=0.405), >12 harvested lymph nodes (P= 0.069), lymphocytic infiltration (P=0.912), venous invasion (P= 0.105), and five-year overall survival (P=0.413). Conclusions The results of the current study suggest that tumour size on its own may not have a significant predictive value in oncological or survival outcomes in patients undergoing curative surgery for colon or rectum cancer. Competing Interests: The authors have declared that no competing interests exist. (Copyright © 2022, Hajibandeh et al.)
Databáze:	MEDLINE
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