Inflammatory biomarkers and risk of breast cancer among young women in Latin America: a case-control study.

Autor: Fontvieille E; International Agency for Research on Cancer (IARC/WHO), Nutrition and Metabolism Branch, Lyon, France., His M; International Agency for Research on Cancer (IARC/WHO), Nutrition and Metabolism Branch, Lyon, France., Biessy C; International Agency for Research on Cancer (IARC/WHO), Nutrition and Metabolism Branch, Lyon, France., Navionis AS; International Agency for Research on Cancer (IARC/WHO), Nutrition and Metabolism Branch, Lyon, France., Torres-Mejía G; Centre for Population Health Research, National Institute of Public Health, Cuernavaca, Mexico., Ángeles-Llerenas A; Centre for Population Health Research, National Institute of Public Health, Cuernavaca, Mexico., Alvarado-Cabrero I; Servicio de Patología, Hospital de Oncología, CMN SXXI, Instituto Mexicano del Seguro Social, Ciudad de México, México., Sánchez GI; Group Infection and Cancer, School of Medicine, University of Antioquia, Medellín, Colombia., Navarro E; Grupo Proyecto UNI-Barranquilla, Universidad del Norte, Barranquilla, Colombia., Cortes YR; Hemato Oncologos, Cali, Colombia., Porras C; Agencia Costarricense de Investigaciones Biomédicas (ACIB)-Fundación INCIENSA, San Jose, Costa Rica., Rodriguez AC; Agencia Costarricense de Investigaciones Biomédicas (ACIB)-Fundación INCIENSA, San Jose, Costa Rica., Garmendia ML; Instituto de Nutrición y de Tecnología de los Alimentos, Universidad de Chile, Santiago, Chile., Soto JL; National Institute of Cancer, Santiago, Chile., Moyano L; National Institute of Cancer, Santiago, Chile., Porter PL; Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, USA., Lin MG; Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, USA., Guenthoer J; Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, USA., Romieu I; Centre for Population Health Research, National Institute of Public Health, Cuernavaca, Mexico.; Hubert Department of Global Health, Emory University, Atlanta, Georgia, USA., Rinaldi S; International Agency for Research on Cancer (IARC/WHO), Nutrition and Metabolism Branch, Lyon, France. rinaldis@iarc.fr.
Jazyk: angličtina
Zdroj: BMC cancer [BMC Cancer] 2022 Aug 11; Vol. 22 (1), pp. 877. Date of Electronic Publication: 2022 Aug 11.
DOI: 10.1186/s12885-022-09975-6
Abstrakt: Background: Breast cancer incidence is increasing rapidly in Latin America, with a higher proportion of cases among young women than in developed countries. Studies have linked inflammation to breast cancer development, but data is limited in premenopausal women, especially in Latin America.
Methods: We investigated the associations between serum biomarkers of chronic inflammation (interleukin (IL)-6, IL-8, IL-10, tumor necrosis factor-α (TNF-α), interferon-γ (IFN-γ), leptin, adiponectin) and risk of premenopausal breast cancer among 453 cases and 453 matched, population-based controls from Chile, Colombia, Costa Rica, and Mexico. Odds ratios (OR) were estimated using conditional logistic regression models. Analyses were stratified by size and hormonal receptor status of the tumors.
Results: IL-6 (OR per standard deviation (SD)  = 1.33 (1.11-1.60)) and TNF-α (OR per SD  = 1.32 (1.11-1.58)) were positively associated with breast cancer risk in fully adjusted models. Evidence of heterogeneity by estrogen receptor (ER) status was observed for IL-8 (P-homogeneity = 0.05), with a positive association in ER-negative tumors only. IL-8 (P-homogeneity = 0.06) and TNF-α (P-homogeneity = 0.003) were positively associated with risk in the largest tumors, while for leptin (P-homogeneity = 0.003) a positive association was observed for the smallest tumors only.
Conclusions: The results of this study support the implication of chronic inflammation in breast cancer risk in young women in Latin America. Largest studies of prospective design are needed to confirm these findings in premenopausal women.
(© 2022. The Author(s).)
Databáze: MEDLINE
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