Efficacy of fetal left ventricular modified myocardial performance index in predicting adverse perinatal outcomes in intrahepatic cholestasis of pregnancy.

Autor:	Gök K; Sakarya University, Faculty of Medicine, Department of Obstetrics and Gynecology - Sakarya, Turkey., Takmaz T; Bezmialem University, Faculty of Medicine, Department of Obstetrics and Gynecology - Istanbul, Turkey., Köse O; Sakarya Research and Training Hospital, Department of Obstetrics and Gynecology - Sakarya, Turkey., Kapudere B; Sakarya University, Faculty of Medicine, Department of Obstetrics and Gynecology - Sakarya, Turkey., Tüten N; Kanuni Sultan Süleyman Research and Training Hospital, Department of Obstetrics and Gynecology - Istanbul, Turkey., Bostancı MS; Sakarya University, Faculty of Medicine, Department of Obstetrics and Gynecology - Sakarya, Turkey., Özden S; Sakarya University, Faculty of Medicine, Department of Obstetrics and Gynecology - Sakarya, Turkey.
Jazyk:	angličtina
Zdroj:	Revista da Associacao Medica Brasileira (1992) [Rev Assoc Med Bras (1992)] 2022 Jul; Vol. 68 (7), pp. 917-921.
DOI:	10.1590/1806-9282.20220008
Abstrakt:	Objective: This study aimed to evaluate the effectiveness of fetal left ventricular modified myocardial performance index in predicting adverse perinatal outcomes for intrahepatic cholestasis of pregnancy. Methods: A cross-sectional study was conducted, including 51 women with intrahepatic cholestasis of pregnancy and 80 healthy controls. Using Doppler ultrasonography, E-wave, A-wave, isovolumetric contraction time, isovolumetric relaxation time, and ejection time were recorded and the left ventricular modified myocardial performance index was measured. Results: Findings showed that the mean left ventricular modified myocardial performance index, isovolumetric contraction time, and isovolumetric relaxation time values were statistically significantly higher while the ejection time and E/A ratios were statistically significantly lower in the intrahepatic cholestasis of pregnancy group than the control group. In the intrahepatic cholestasis of pregnancy group, a statistically significant positive correlation was found between left ventricular modified myocardial performance index and adverse perinatal outcomes in the intrahepatic cholestasis of pregnancy group (r=0.478, p<0.001), while a statistically significant negative correlation was found between the E/A ratio and adverse perinatal outcomes (r=-0.701, p<0.001). Conclusions: For intrahepatic cholestasis of pregnancy cases, high fetal left ventricular modified myocardial performance index values were an indicator of ventricular dysfunction, and this correlated with negative perinatal outcomes.
Databáze:	MEDLINE
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