Decline in head circumference growth and associated factors in congenital Zika syndrome.

Autor:	Takahasi EHM; Departamento de Saúde Pública, Universidade Federal do Maranhão, São Luís, Brasil.; Rede Sarah de Hospitais de Reabilitação, São Luís, Brasil., Alves MTSSBE; Departamento de Saúde Pública, Universidade Federal do Maranhão, São Luís, Brasil., Ribeiro MRC; Departamento de Medicina III, Universidade Federal do Maranhão, São Luís, Brasil., Santos AMD; Departamento de Saúde Pública, Universidade Federal do Maranhão, São Luís, Brasil., Campos MAG; Universidade Federal do Maranhão, São Luís, Brasil., Simões VMF; Universidade Federal do Maranhão, São Luís, Brasil., Amaral GA; Rede Sarah de Hospitais de Reabilitação, São Luís, Brasil., Sousa PDS; Centro de Referência em Neurodesenvolvimento, Assistência e Reabilitação da Criança, São Luís, Brasil., Miranda-Filho DB; Faculdade de Ciências Médicas, Universidade Federal de Pernambuco, Recife, Brasil., Silva AAMD; Departamento de Saúde Pública, Universidade Federal do Maranhão, São Luís, Brasil.
Jazyk:	angličtina
Zdroj:	Cadernos de saude publica [Cad Saude Publica] 2022 Aug 08; Vol. 38 (8), pp. e00296021. Date of Electronic Publication: 2022 Aug 08 (Print Publication: 2022).
DOI:	10.1590/0102-311XEN296021
Abstrakt:	Little is known about the evolution of head circumference (HC) in children with congenital Zika syndrome (CZS). This study aims to evaluate HC growth in children with CZS in the first three years of life and identify associated factors. HC data obtained at birth and in neuropediatric consultations from 74 children with CZS were collected from the Child's Health Handbook, parents' reports, and medical records. Predictors of HC z-score were investigated using different mixed-effects models; Akaike's information criterion was used for model selection. The HC z-score decreased from -2.7 ± 1.6 at birth to -5.5 ± 2.2 at 3 months of age, remaining relatively stable thereafter. In the selected adjusted model, the presence of severe brain parenchymal atrophy and maternal symptoms of infection in the first trimester of pregnancy were associated with a more pronounced reduction in the HC z-score in the first three years of life. The decrease of HC z-score in CZS children over the first three months demonstrated a reduced potential for growth and development of the central nervous system of these children. The prognosis of head growth in the first 3 years of life is worse when maternal infection occurs in the first gestational trimester and in children who have severe brain parenchymal atrophy.
Databáze:	MEDLINE
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