Arterial Stiffness and Diabetes Risk in Framingham Heart Study and UK Biobank.

Autor:	Cohen JB; Renal-Electrolyte and Hypertension Division (J.B.C., R.R.T.), Perelman School of Medicine, University of Pennsylvania, Philadelphia.; Department of Biostatistics, Epidemiology, and Informatics (J.B.C.), Perelman School of Medicine, University of Pennsylvania, Philadelphia., Mitchell GF; Cardiovascular Engineering, Inc, Norwood, MA (G.F.M.)., Gill D; Department of Epidemiology and Biostatistics, School of Public Health, MRC Centre for Environment and Health, Imperial College London, United Kingdom (D.G.)., Burgess S; Medical Research Council Biostatistics Unit, School of Clinical Medicine (S.B.), University of Cambridge, United Kingdom.; Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care (S.B.), University of Cambridge, United Kingdom., Rahman M; Department of Medicine, Case Western University, University Hospitals Case Medical Center, Cleveland, OH (M.R.)., Hanff TC; Division of Cardiovascular Medicine, University of Utah School of Medicine, Salt Lake City (T.C.H.)., Ramachandran VS; Department of Medicine, Boston University School of Medicine, MA (V.S.R.).; Department of Epidemiology, Boston University School of Public Health, MA (V.S.R.).; Framingham Heart Study, Framingham, MA (V.S.R., K.M.M.)., Mutalik KM; Framingham Heart Study, Framingham, MA (V.S.R., K.M.M.)., Townsend RR; Renal-Electrolyte and Hypertension Division (J.B.C., R.R.T.), Perelman School of Medicine, University of Pennsylvania, Philadelphia., Chirinos JA; Division of Cardiology (J.A.C.), Perelman School of Medicine, University of Pennsylvania, Philadelphia.
Jazyk:	angličtina
Zdroj:	Circulation research [Circ Res] 2022 Sep 02; Vol. 131 (6), pp. 545-554. Date of Electronic Publication: 2022 Aug 10.
DOI:	10.1161/CIRCRESAHA.122.320796
Abstrakt:	Background: Microvascular damage from large artery stiffness (LAS) in pancreatic, hepatic, and skeletal muscles may affect glucose homeostasis. Our goal was to evaluate the association between LAS and the risk of type 2 diabetes using prospectively collected, carefully phenotyped measurements of LAS as well as Mendelian randomization analyses. Methods: Carotid-femoral pulse wave velocity (CF-PWV) and brachial and central pulse pressure were measured in 5676 participants of the FHS (Framingham Heart Study) without diabetes. We used Cox proportional hazards regression to evaluate the association of CF-PWV and pulse pressure with incident diabetes. We subsequently performed 2-sample Mendelian randomization analyses evaluating the associations of genetically predicted brachial pulse pressure with type 2 diabetes in the UKBB (United Kingdom Biobank). Results: In FHS, individuals with higher CF-PWV were older, more often male, and had higher body mass index and mean arterial pressure compared to those with lower CF-PWV. After a median follow-up of 7 years, CF-PWV and central pulse pressure were associated with an increased risk of new-onset diabetes (per SD increase, multivariable-adjusted CF-PWV hazard ratio, 1.36 [95% CI, 1.03-1.76]; P =0.030; central pulse pressure multivariable-adjusted CF-PWV hazard ratio, 1.26 [95% CI, 1.08-1.48]; P =0.004). In United Kingdom Biobank, genetically predicted brachial pulse pressure was associated with type 2 diabetes, independent of mean arterial pressure (adjusted odds ratio, 1.16 [95% CI, 1.00-1.35]; P =0.049). Conclusions: Using prospective cohort data coupled with Mendelian randomization analyses, we found evidence supporting that greater LAS is associated with increased risk of developing diabetes. LAS may play an important role in glucose homeostasis and may serve as a useful marker of future diabetes risk.
Databáze:	MEDLINE
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