Multicenter Analysis of Cardiometabolic-related Diagnoses in Transgender and Gender-Diverse Youth: A PEDSnet Study.

Autor:	Valentine A; University of Colorado Anschutz Medical Campus, Department of Pediatrics, Aurora, Colorado 80045, USA.; Children's Hospital Colorado, Division of Endocrinology, Aurora, Colorado 80045USA., Davis S; University of Colorado Anschutz Medical Campus, Department of Pediatrics, Aurora, Colorado 80045, USA.; Children's Hospital Colorado, Division of Endocrinology, Aurora, Colorado 80045USA., Furniss A; University of Colorado Adult & Child Consortium for Health Outcomes Research and Delivery Sciences (ACCORDS), Aurora, Colorado 80045, USA., Dowshen N; University of Pennsylvania, Perelman School of Medicine, Philadelphia, Pennsylvania 19104, USA., Kazak AE; Thomas Jefferson University, Sidney Kimmel Medical College, Philadelphia, Pennsylvania 19107, USA., Lewis C; Washington University School of Medicine, St Louis, Missouri 63110, USA., Loeb DF; University of Colorado Anschutz Medical Campus, Department of Medicine, Aurora, Colorado 80045, USA., Nahata L; Center for Biobehavioral Health, Abigail Wexner Research Institute, Columbus, Ohio 43215, USA.; Division of Endocrinology, Nationwide Children's Hospital, Columbus, Ohio 43205, USA., Pyle L; University of Colorado Anschutz Medical Campus, Department of Pediatrics, Aurora, Colorado 80045, USA.; University of Colorado School of Public Health, Department of Biostatistics and Informatics, Aurora, Colorado 80045, USA., Schilling LM; University of Colorado Anschutz Medical Campus, Department of Medicine, Aurora, Colorado 80045, USA.; University of Colorado Data Science to Patient Value Initiative, Aurora, CO 80045, USA., Sequeira GM; Seattle Children's Research Institute, Seattle, Washington 98121, USA., Nokoff N; University of Colorado Anschutz Medical Campus, Department of Pediatrics, Aurora, Colorado 80045, USA.; Children's Hospital Colorado, Division of Endocrinology, Aurora, Colorado 80045USA.
Jazyk:	angličtina
Zdroj:	The Journal of clinical endocrinology and metabolism [J Clin Endocrinol Metab] 2022 Sep 28; Vol. 107 (10), pp. e4004-e4014.
DOI:	10.1210/clinem/dgac469
Abstrakt:	Context: Studies on cardiometabolic health in transgender and gender-diverse youth (TGDY) are limited to small cohorts. Objective: This work aimed to determine the odds of cardiometabolic-related diagnoses in TGDY compared to matched controls in a cross-sectional analysis, using a large, multisite database (PEDSnet). Methods: Electronic health record data (2009-2019) were used to determine odds of cardiometabolic-related outcomes based on diagnosis, anthropometric, and laboratory data using logistic regression among TGDY youth vs controls. The association of gender-affirming hormone therapy (GAHT) with these outcomes was examined separately among TGDY. TGDY (n = 4172) were extracted from 6 PEDSnet sites and propensity-score matched on 8 variables to controls (n = 16 648). Main outcomes measures included odds of having cardiometabolic-related diagnoses among TGDY compared to matched controls, and among TGDY prescribed GAHT compared to those not prescribed GAHT. Results: In adjusted analyses, TGDY had higher odds of overweight/obesity (1.2; 95% CI, 1.1-1.3) than controls. TGDY with a testosterone prescription alone or in combination with a gonadotropin-releasing hormone agonist (GnRHa) had higher odds of dyslipidemia (1.7; 95% CI, 1.3-2.3 and 3.7; 95% CI, 2.1-6.7, respectively) and liver dysfunction (1.5; 95% CI, 1.1-1.9 and 2.5; 95% CI, 1.4-4.3) than TGDY not prescribed GAHT. TGDY with a testosterone prescription alone had higher odds of overweight/obesity (1.8; 95% CI, 1.5-2.1) and hypertension (1.6 95% CI, 1.2-2.2) than those not prescribed testosterone. Estradiol and GnRHa alone were not associated with greater odds of cardiometabolic-related diagnoses. Conclusion: TGDY have increased odds of overweight/obesity compared to matched controls. Screening and tailored weight management, sensitive to the needs of TGDY, are needed. (© The Author(s) 2022. Published by Oxford University Press on behalf of the Endocrine Society. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.)
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu