Seizures following COVID-19 vaccination in Mexico: A nationwide observational study.

Autor: Núñez I; Department of Medical Education, Salvador Zubirán National Institute of Medical Sciences and Nutrition, Mexico City, Mexico., García-Grimshaw M; Department of Neurology and Psychiatry, Salvador Zubirán National Institute of Medical Sciences and Nutrition, Mexico City, Mexico., Castillo Valencia CY; Department of Neurology, National Institute of Neurology and Neurosurgery, Mexico City, Mexico., Aguilera Callejas DE; Department of Neurology, National Institute of Neurology and Neurosurgery, Mexico City, Mexico., Moya Alfaro ML; Department of Neurology, National Institute of Neurology and Neurosurgery, Mexico City, Mexico., Saniger-Alba MDM; Department of Neurology and Psychiatry, Salvador Zubirán National Institute of Medical Sciences and Nutrition, Mexico City, Mexico., Gutiérrez-Romero A; Department of Neurology, National Institute of Neurology and Neurosurgery, Mexico City, Mexico., Carrillo-Mezo R; Department of Neurology, National Institute of Neurology and Neurosurgery, Mexico City, Mexico., Ceballos-Liceaga SE; Directorate-General for Epidemiology, Ministry of Health, Mexico City, Mexico., Baptista-Rosas RC; Department of Health Sciences-Disease as an Individual Process, University Center of Tonalá, University of Guadalajara, Guadalajara, Mexico.; Critical Medicine Intervention Unit, Western General Hospital, Jalisco Ministry of Health, Zapopan, Mexico., López-Gatell H; Undersecretary of Prevention and Health Promotion, Ministry of Health, Mexico City, Mexico., Reyes-Terán G; Coordinating Commission of National Institutes of Health and High Specialty Hospitals, Ministry of Health, Mexico City, Mexico., Díaz-Ortega JL; National Center for Child and Adolescent Health, Ministry of Health, Mexico City, Mexico., Arauz A; Department of Neurology, National Institute of Neurology and Neurosurgery, Mexico City, Mexico., Valdés-Ferrer SI; Department of Neurology and Psychiatry, Salvador Zubirán National Institute of Medical Sciences and Nutrition, Mexico City, Mexico., Hernández-Vanegas LE; Department of Neurology, National Institute of Neurology and Neurosurgery, Mexico City, Mexico.
Jazyk: angličtina
Zdroj: Epilepsia [Epilepsia] 2022 Oct; Vol. 63 (10), pp. e144-e149. Date of Electronic Publication: 2022 Aug 20.
DOI: 10.1111/epi.17390
Abstrakt: The COVID-19 pandemic led to the development and emergency approval of an array of effective vaccines against SARS-CoV-2. Given the relatively small number of patients included in vaccine trials, postapproval epidemiological surveillance is crucial to detect infrequent vaccine-related adverse events. We conducted a nationwide retrospective descriptive study evaluating the incidence of seizures among recipients of SARS-CoV-2 vaccines in Mexico from December 24, 2020 (date of administration of first doses nationwide) to October 29, 2021. Among 81 916 351 doses of any vaccine that were administered, we documented seizures in 53 patients, of which 31 (60%) were new onset seizures. The incidence rate of seizures per million doses was highest for mRNA-1273 (Moderna) with 2.73 per million, followed by BNT162b2 (Pfizer-BioNTech) with 1.02 per million, and Ad5-nCoV (CanSino) with 1.01 per million. Thus, we found that seizures following SARS-CoV-2 vaccination are exceedingly rare events.
(© 2022 International League Against Epilepsy.)
Databáze: MEDLINE
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