Protocol for spike-triggered closed-loop auditory stimulation during sleep in patients with epilepsy.
| Autor: | Ngo HV; Department of Psychology, University of Lübeck, 23562 Lübeck, Germany; Center for Brain, Behavior and Metabolism, University of Lübeck, 23562 Lübeck, Germany. Electronic address: ho.ngo@uni-luebeck.de., Born J; Institute of Medical Psychology and Behavioral Neurobiology, University of Tübingen, 72076 Tübingen, Germany; Centre for Integrative Neuroscience, University of Tübingen, 72076 Tübingen, Germany., Klinzing JG; Institute of Medical Psychology and Behavioral Neurobiology, University of Tübingen, 72076 Tübingen, Germany; Centre for Integrative Neuroscience, University of Tübingen, 72076 Tübingen, Germany; Bit&Brain Technologies SL (Bitbrain), 50008 Zaragoza, Spain. Electronic address: jens.klinzing@uni-tuebingen.de. |
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| Jazyk: | angličtina |
| Zdroj: | STAR protocols [STAR Protoc] 2022 Jul 31; Vol. 3 (3), pp. 101505. Date of Electronic Publication: 2022 Jul 31 (Print Publication: 2022). |
| DOI: | 10.1016/j.xpro.2022.101505 |
| Abstrakt: | Several epilepsies are characterized by interictal spikes in the electroencephalogram occurring preferentially during sleep. We present a closed-loop auditory stimulation protocol with potential for treating sleep epilepsies. We describe the pre-sleep preparations, sleep recordings, the auditory stimulation, in which tones are triggered upon spike detection, and post-sleep procedures. This protocol has been shown to decrease likelihood and amplitude of subsequent spikes in patients with BECTS (Benign epilepsy with centrotemporal spikes) and can be applied to study non-pharmacological treatments of sleep epilepsies. For complete details on the use and execution of this protocol, please refer to Klinzing et al. (2021). Competing Interests: A patent has been filed by J.G.K. and H.-V.V.N. based on these results. After developing the protocol and conducting the first study (Klinzing et al., 2021), J.G.K. was employed by the neurotechnology company Bitbrain. Bitbrain in no way influenced the development or application of the protocol or the content of this or previous manuscripts. (© 2022 The Author(s).) |
| Databáze: | MEDLINE |
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