Agonist-antagonist muscle strain in the residual limb preserves motor control and perception after amputation.

Autor: Song H; K. Lisa Yang Center for Bionics, Massachusetts Institute of Technology, Cambridge, MA USA.; Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA USA., Israel EA; K. Lisa Yang Center for Bionics, Massachusetts Institute of Technology, Cambridge, MA USA., Gutierrez-Arango S; K. Lisa Yang Center for Bionics, Massachusetts Institute of Technology, Cambridge, MA USA., Teng AC; K. Lisa Yang Center for Bionics, Massachusetts Institute of Technology, Cambridge, MA USA.; Mechanical Engineering Department, Massachusetts Institute of Technology, Cambridge, MA USA., Srinivasan SS; K. Lisa Yang Center for Bionics, Massachusetts Institute of Technology, Cambridge, MA USA.; Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA USA., Freed LE; K. Lisa Yang Center for Bionics, Massachusetts Institute of Technology, Cambridge, MA USA., Herr HM; K. Lisa Yang Center for Bionics, Massachusetts Institute of Technology, Cambridge, MA USA.; Harvard Medical School, Cambridge, MA USA.
Jazyk: angličtina
Zdroj: Communications medicine [Commun Med (Lond)] 2022 Aug 05; Vol. 2, pp. 97. Date of Electronic Publication: 2022 Aug 05 (Print Publication: 2022).
DOI: 10.1038/s43856-022-00162-z
Abstrakt: Background: Elucidating underlying mechanisms in subject-specific motor control and perception after amputation could guide development of advanced surgical and neuroprosthetic technologies. In this study, relationships between preserved agonist-antagonist muscle strain within the residual limb and preserved motor control and perception capacity are investigated.
Methods: Fourteen persons with unilateral transtibial amputations spanning a range of ages, etiologies, and surgical procedures underwent evaluations involving free-space mirrored motions of their lower limbs. Research has shown that varied motor control in biologically intact limbs is executed by the activation of muscle synergies. Here, we assess the naturalness of phantom joint motor control postamputation based on extracted muscle synergies and their activation profiles. Muscle synergy extraction, degree of agonist-antagonist muscle strain, and perception capacity are estimated from electromyography, ultrasonography, and goniometry, respectively.
Results: Here, we show significant positive correlations ( P  < 0.005-0.05) between sensorimotor responses and residual limb agonist-antagonist muscle strain. Identified trends indicate that preserving even 20-26% of agonist-antagonist muscle strain within the residuum compared to a biologically intact limb is effective in preserving natural motor control postamputation, though preserving limb perception capacity requires more (61%) agonist-antagonist muscle strain preservation.
Conclusions: The results suggest that agonist-antagonist muscle strain is a characteristic, readily ascertainable residual limb structural feature that can help explain variability in amputation outcome, and agonist-antagonist muscle strain preserving surgical amputation strategies are one way to enable more effective and biomimetic sensorimotor control postamputation.
Competing Interests: Competing interestsThe authors declare no competing interests.
(© The Author(s) 2022.)
Databáze: MEDLINE
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