Vitamin D, oral health, and disease characteristics in juvenile idiopathic arthritis: a multicenter cross-sectional study.

Autor: Cetrelli L; Center of Oral Health Services and Research (TkMidt), Trondheim, Norway. lence@tkmidt.no.; The Public Dental Health Service, Trøndelag County, Trondheim, Norway. lence@tkmidt.no.; Department of Clinical and Molecular Medicine, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology (NTNU), Trondheim, Norway. lence@tkmidt.no., Bletsa A; Oral Health Centre of Expertise in Western Norway (TkV), Bergen, Norway.; Department of Clinical Dentistry, The Faculty of Medicine, University of Bergen, Bergen, Norway., Lundestad A; Department of Clinical and Molecular Medicine, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology (NTNU), Trondheim, Norway.; Department of Pediatrics, St. Olavs University Hospital, Trondheim, Norway., Gil EG; Department of Clinical Dentistry, The Faculty of Medicine, University of Bergen, Bergen, Norway., Fischer J; Department of Clinical Dentistry, The Faculty of Medicine, University of Bergen, Bergen, Norway., Halbig J; Public Dental Health Service Competence Centre of Northern Norway (TkNN), Tromsø, Norway.; Department of Clinical Medicine, The Arctic University of Norway, Tromsø (UiT), Norway., Frid P; Public Dental Health Service Competence Centre of Northern Norway (TkNN), Tromsø, Norway.; Department of Clinical Dentistry, The Arctic University of Norway, Tromsø (UiT), Norway.; Division of Oral and Maxillofacial Surgery, Department of Otorhinolaryngology, University Hospital North Norway, Tromsø, Norway., Angenete O; Department of Radiology and Nuclear Medicine, St Olav Hospital HF, Trondheim University Hospital, Trondheim, Norway.; Department of Circulation and Medical Imaging, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology, Trondheim, Norway., Lillevoll I; Center of Oral Health Services and Research (TkMidt), Trondheim, Norway., Rosén A; Department of Clinical Dentistry, The Faculty of Medicine, University of Bergen, Bergen, Norway.; Department of Oral and Maxillofacial Surgery, Haukeland University Hospital, Bergen, Norway., Tylleskär KB; The Children's Clinic at Haukeland University Hospital, Bergen, Norway., Luukko K; Department of Clinical Dentistry, The Faculty of Medicine, University of Bergen, Bergen, Norway., Nordal E; Department of Clinical Medicine, The Arctic University of Norway, Tromsø (UiT), Norway.; Department of Pediatrics, University Hospital of Northern Norway, Tromsø, Norway., Åstrøm AN; Oral Health Centre of Expertise in Western Norway (TkV), Bergen, Norway.; Department of Clinical Dentistry, The Faculty of Medicine, University of Bergen, Bergen, Norway., Skeie MS; Center of Oral Health Services and Research (TkMidt), Trondheim, Norway.; Department of Clinical Dentistry, The Faculty of Medicine, University of Bergen, Bergen, Norway., Feuerherm AJ; Center of Oral Health Services and Research (TkMidt), Trondheim, Norway., Sen A; Center of Oral Health Services and Research (TkMidt), Trondheim, Norway.; Department of Clinical and Molecular Medicine, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology (NTNU), Trondheim, Norway., Rygg M; Department of Clinical and Molecular Medicine, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology (NTNU), Trondheim, Norway.; Department of Pediatrics, St. Olavs University Hospital, Trondheim, Norway.
Jazyk: angličtina
Zdroj: BMC oral health [BMC Oral Health] 2022 Aug 08; Vol. 22 (1), pp. 333. Date of Electronic Publication: 2022 Aug 08.
DOI: 10.1186/s12903-022-02349-1
Abstrakt: Background: Vitamin D deficiency has been associated with autoimmune diseases and oral health. Knowledge about the association between vitamin D status and oral conditions in JIA is limited. We aimed to investigate vitamin D status in a cohort of Norwegian children and adolescents with JIA and possible associations between serum vitamin D levels, clinical indicators of oral health, and JIA disease characteristics.
Methods: This multi-center, cross-sectional study, included individuals with JIA aged 4-16 years from three geographically spread regions in Norway. Demographic data, age at disease onset, disease duration, JIA category, disease status, medication, and vitamin D intake were registered. One blood sample per individual was analyzed for 25(OH) vitamin D, and the level of insufficiency was defined as < 50 nmol/L. A clinical oral examination was performed applying commonly used indices in epidemiological studies of dental caries, dental erosion, enamel defects, gingival bleeding, and oral hygiene. Serum vitamin D was used as exposure variable in multivariable regression analyses to estimate the associations between insufficient vitamin D level, JIA disease status, and oral conditions, with adjustments for age, sex, geographical region, BMI, seasonal blood sampling, and parental education.
Results: Among the 223 participants with JIA, 97.3% were Caucasians, 59.2% were girls, and median age was 12.6 years. Median disease duration was 4.6 years, and 44.4% had oligoarticular JIA. Mean serum vitamin D level was 61.4 nmol/L and 29.6% had insufficient levels. Vitamin D levels did not differ between sexes, but between regions, iso-BMI categories, age groups, and seasons for blood sampling. Insufficient vitamin D levels were associated with dentin caries (adjusted OR 2.89, 95% CI 1.43-5.86) and gingival bleeding (adjusted OR 2.36, 95% CI 1.10-5.01). No associations were found with active JIA disease or more severe disease characteristics.
Conclusion: In our study, nearly 30% had vitamin D insufficiency, with a particularly high prevalence among adolescents. Vitamin D insufficiency was associated with dentin caries and gingival bleeding, but not with JIA disease activity. These results point to the need for a multidisciplinary approach in the follow-up of children with JIA, including an increased focus on vitamin D status and oral health.
(© 2022. The Author(s).)
Databáze: MEDLINE
Externí odkaz: