Role of metabolism in uropathogenic Escherichia coli.

Autor: Chan CCY; Department of Biological Science, University of Calgary, Calgary, AB, T2N 1N4, Canada., Lewis IA; Department of Biological Science, University of Calgary, Calgary, AB, T2N 1N4, Canada. Electronic address: ian.lewis2@ucalgary.ca.
Jazyk: angličtina
Zdroj: Trends in microbiology [Trends Microbiol] 2022 Dec; Vol. 30 (12), pp. 1174-1204. Date of Electronic Publication: 2022 Aug 06.
DOI: 10.1016/j.tim.2022.06.003
Abstrakt: Uropathogenic Escherichia coli (UPEC) is responsible for more than 75% of urinary tract infections (UTIs) and has been studied extensively to better understand the molecular underpinnings of infection and pathogenesis. Although the macromolecular adaptations UPEC employs - including the expression of virulence factors, adhesion molecules, and iron-acquisition systems - are well described, the role that metabolism plays in enabling infection is still unclear. However, a growing body of literature shows that metabolic function can have a profound impact on which strains can colonize the urinary tract. The goal of this review is to critically appraise this emerging body of literature to better understand the role that nutritional selection plays in enabling urinary tract colonization and the progression of UTIs.
Competing Interests: Declaration of interests No interests are declared.
(Copyright © 2022 Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
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