Rodent models in translational circadian photobiology.

Autor:	Tir S; Sir Jules Thorn Sleep and Circadian Neuroscience Institute (SCNi), Kavli Institute for NanoScience Discovery, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, United Kingdom., Steel LCE; Sir Jules Thorn Sleep and Circadian Neuroscience Institute (SCNi), Kavli Institute for NanoScience Discovery, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, United Kingdom., Tam SKE; Sir Jules Thorn Sleep and Circadian Neuroscience Institute (SCNi), Kavli Institute for NanoScience Discovery, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, United Kingdom., Semo M; Sir Jules Thorn Sleep and Circadian Neuroscience Institute (SCNi), Kavli Institute for NanoScience Discovery, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, United Kingdom., Pothecary CA; Sir Jules Thorn Sleep and Circadian Neuroscience Institute (SCNi), Kavli Institute for NanoScience Discovery, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, United Kingdom., Vyazovskiy VV; Sir Jules Thorn Sleep and Circadian Neuroscience Institute (SCNi), Kavli Institute for NanoScience Discovery, Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, United Kingdom., Foster RG; Sir Jules Thorn Sleep and Circadian Neuroscience Institute (SCNi), Kavli Institute for NanoScience Discovery, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, United Kingdom., Peirson SN; Sir Jules Thorn Sleep and Circadian Neuroscience Institute (SCNi), Kavli Institute for NanoScience Discovery, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, United Kingdom. Electronic address: stuart.peirson@eye.ox.ac.uk.
Jazyk:	angličtina
Zdroj:	Progress in brain research [Prog Brain Res] 2022; Vol. 273 (1), pp. 97-116. Date of Electronic Publication: 2022 Mar 21.
DOI:	10.1016/bs.pbr.2022.02.015
Abstrakt:	Over the last decades remarkable advances have been made in the understanding of the photobiology of circadian rhythms. The identification of a third photoreceptive system in the mammalian eye, in addition to the rods and cones that mediate vision, has transformed our appreciation of the role of light in regulating physiology and behavior. These photosensitive retinal ganglion cells (pRGCs) express the blue-light sensitive photopigment melanopsin and project to the suprachiasmatic nuclei (SCN)-the master circadian pacemaker-as well as many other brain regions. Much of our understanding of the fundamental mechanisms of the pRGCs, and the processes that they regulate, comes from mouse and other rodent models. Here we describe the contribution of rodent models to circadian photobiology, including both their strengths and limitations. In addition, we discuss how an appreciation of both rodent and human data is important for translational circadian photobiology. Such an approach enables a bi-directional flow of information whereby an understanding of basic mechanisms derived from mice can be integrated with studies from humans. Progress in this field is being driven forward at several levels of analysis, not least by the use of personalized light measurements and photoreceptor specific stimuli in human studies, and by studying the impact of environmental, rather than laboratory, lighting on different rodent models. (Copyright © 2022 Elsevier B.V. All rights reserved.)
Databáze:	MEDLINE
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