| Autor: |
Pulido OM, Bencosme SA, de Bold ML, de Bold AJ |
| Jazyk: |
angličtina |
| Zdroj: |
Diabetologia [Diabetologia] 1978 Sep; Vol. 15 (3), pp. 197-204. |
| DOI: |
10.1007/BF00421239 |
| Abstrakt: |
The role of intracellular pancreatic B cell serotonin in the dynamics of insulin release was investigated in an in situ perfused rat pancreas preparation. Animals were pretreated with 5-hydroxytryptophan (5-HTP) to increase the intracellular levels of serotonin (5-HT) as shown by fluorescence histochemistry. Despite a clear induction of intracellular 5-HT fluorescence in pancreatic islets neither the pattern nor the total amount of insulin released were significantly modified after perfusion with either glucose or tolbutamide. However, the L-amino acid decarboxylase inhibitor, RO 4--4602, significantly decreased both phases of glucose-mediated insulin release in normal animals as well as in those receiving 5-HTP. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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