Effectiveness of Early Time-Restricted Eating for Weight Loss, Fat Loss, and Cardiometabolic Health in Adults With Obesity: A Randomized Clinical Trial.

Autor:	Jamshed H; Department of Nutrition Sciences, University of Alabama at Birmingham.; Department of Integrated Sciences and Mathematics, Habib University, Karachi, Sindh, Pakistan., Steger FL; Department of Nutrition Sciences, University of Alabama at Birmingham.; Department of Endocrinology, Genetics and Metabolism, University of Kansas Medical Center, Kansas City., Bryan DR; Department of Nutrition Sciences, University of Alabama at Birmingham., Richman JS; Department of Surgery, University of Alabama at Birmingham., Warriner AH; Department of Medicine, University of Alabama at Birmingham., Hanick CJ; Department of Nutrition Sciences, University of Alabama at Birmingham., Martin CK; Ingestive Behavior Laboratory, Pennington Biomedical Research Center, Baton Rouge, Louisiana., Salvy SJ; Cedars-Sinai Medical Center, Los Angeles, California., Peterson CM; Department of Nutrition Sciences, University of Alabama at Birmingham.
Jazyk:	angličtina
Zdroj:	JAMA internal medicine [JAMA Intern Med] 2022 Sep 01; Vol. 182 (9), pp. 953-962.
DOI:	10.1001/jamainternmed.2022.3050
Abstrakt:	Importance: It is unclear how effective intermittent fasting is for losing weight and body fat, and the effects may depend on the timing of the eating window. This randomized trial compared time-restricted eating (TRE) with eating over a period of 12 or more hours while matching weight-loss counseling across groups. Objective: To determine whether practicing TRE by eating early in the day (eTRE) is more effective for weight loss, fat loss, and cardiometabolic health than eating over a period of 12 or more hours. Design, Setting, and Participants: The study was a 14-week, parallel-arm, randomized clinical trial conducted between August 2018 and April 2020. Participants were adults aged 25 to 75 years with obesity and who received weight-loss treatment through the Weight Loss Medicine Clinic at the University of Alabama at Birmingham Hospital. Interventions: All participants received weight-loss treatment (energy restriction [ER]) and were randomized to eTRE plus ER (8-hour eating window from 7:00 to 15:00) or control eating (CON) plus ER (≥12-hour window). Main Outcomes and Measures: The co-primary outcomes were weight loss and fat loss. Secondary outcomes included blood pressure, heart rate, glucose levels, insulin levels, and plasma lipid levels. Results: Ninety participants were enrolled (mean [SD] body mass index, 39.6 [6.7]; age, 43 [11] years; 72 [80%] female). The eTRE+ER group adhered 6.0 (0.8) days per week. The eTRE+ER intervention was more effective for losing weight (-2.3 kg; 95% CI, -3.7 to -0.9 kg; P = .002) but did not affect body fat (-1.4 kg; 95% CI, -2.9 to 0.2 kg; P = .09) or the ratio of fat loss to weight loss (-4.2%; 95% CI, -14.9 to 6.5%; P = .43). The effects of eTRE+ER were equivalent to reducing calorie intake by an additional 214 kcal/d. The eTRE+ER intervention also improved diastolic blood pressure (-4 mm Hg; 95% CI, -8 to 0 mm Hg; P = .04) and mood disturbances, including fatigue-inertia, vigor-activity, and depression-dejection. All other cardiometabolic risk factors, food intake, physical activity, and sleep outcomes were similar between groups. In a secondary analysis of 59 completers, eTRE+ER was also more effective for losing body fat and trunk fat than CON+ER. Conclusions and Relevance: In this randomized clinical trial, eTRE was more effective for losing weight and improving diastolic blood pressure and mood than eating over a window of 12 or more hours at 14 weeks. Trial Registration: ClinicalTrials.gov Identifier: NCT03459703.
Databáze:	MEDLINE
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