The clinical relevance of various methods of classifying ipsilateral breast tumour recurrence as either true local recurrence or new primary.

Autor: Jobsen JJ; Department of Epidemiology, Medisch Spectrum Twente, Koningstraat 1, 7512 KZ, Enschede, The Netherlands. jjjobsen@hetnet.nl.; Breast Clinic Oost-Nederland, Ziekenhuis Groep Twente, Hengelo, The Netherlands. jjjobsen@hetnet.nl., Struikmans H; Department of Radiation Oncology, Leiden University Medical Centre, Leiden, The Netherlands., Siemerink E; Department of Internal Medicine, Ziekenhuis Groep Twente, Hengelo, The Netherlands., van der Palen J; Department of Epidemiology, Medisch Spectrum Twente, Koningstraat 1, 7512 KZ, Enschede, The Netherlands.; Section Cognition, Data and Education, Faculty of Behavioral Science, University of Twente, Enschede, The Netherlands., Heijmans HJ; Breast Clinic Oost-Nederland, Ziekenhuis Groep Twente, Hengelo, The Netherlands.; Department of Surgery, Ziekenhuis Groep Twente, Hengelo, The Netherlands.
Jazyk: angličtina
Zdroj: Breast cancer research and treatment [Breast Cancer Res Treat] 2022 Oct; Vol. 195 (3), pp. 249-262. Date of Electronic Publication: 2022 Aug 08.
DOI: 10.1007/s10549-022-06680-7
Abstrakt: Purpose: Describes the relevance of -various classification methods for ipsilateral breast tumour recurrence (IBTR) as either true recurrence (TR) or new primary (NP) on both disease-specific survival (DSS) and distant metastasis-free survival (DMFS).
Method: Two hundred and thirty-four of 4359 women undergoing breast-conserving therapy experienced IBTR. We compared the impact of four known classification methods and two newly created classification methods.
Results: For three of the methods, a better DSS was observed for NP compared to TR with the hazard ratio (HR) ranging from 0.5 to 0.6. The new Twente method classification, comprising all classification criteria of three known methods, and the new Morphology method, using only morphological criteria, had the best HR and confidence interval with a HR 0.5 (95% CI 0.2-1.0) and a HR 0.5 (95% CI 0.3-1.1), respectively. For DMFS, the HR for NP compared to TR ranged from 0.6 to 0.9 for all six methods. The new Morphology method and the Twente method noted the best HR and confidence intervals with a HR 0.6 (95% CI 0.3-1.1) and a HR 0.6 (95% CI 0.4-1.2), respectively.
Conclusion: IBTR classified as TR or NP has a prognostic value for both DSS and DMFS, but depends on the classification method used. Developing and validating a generally accepted form of classification are imperative for using TR and NP in clinical practice.
(© 2022. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.)
Databáze: MEDLINE
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