The prospective screening for SARS-CoV-2 S1/S2 antibodies delineates the factual incidence of COVID-19 and shows a sustained serological response post COVID-19 in kidney transplant recipients.

Autor:	Firket L; Division of Nephrology, University of Liege Hospital (ULiege CHU), Liege, Belgium., Bouquegneau A; Division of Nephrology, University of Liege Hospital (ULiege CHU), Liege, Belgium., Seidel L; Division of Biostatistics, University of Liege Hospital (ULiege CHU), Liege, Belgium., Bonvoisin C; Division of Nephrology, University of Liege Hospital (ULiege CHU), Liege, Belgium., Grosch S; Division of Nephrology, University of Liege Hospital (ULiege CHU), Liege, Belgium., Hayette MP; Division of Microbiology, University of Liege Hospital (ULiege CHU), Liege, Belgium., Jouret F; Division of Nephrology, University of Liege Hospital (ULiege CHU), Liege, Belgium.; Laboratory of Translational Research in Nephrology, University of Liege GIGA Research Center, ULiege, Belgium., Weekers L; Division of Nephrology, University of Liege Hospital (ULiege CHU), Liege, Belgium.
Jazyk:	angličtina
Zdroj:	Acta clinica Belgica [Acta Clin Belg] 2023 Jun; Vol. 78 (3), pp. 200-205. Date of Electronic Publication: 2022 Aug 08.
DOI:	10.1080/17843286.2022.2108978
Abstrakt:	Background: The impact of immunosuppression on the occurrence of Coronavirus Disease 2019 (COVID-19) remains unclear. Methods: We conducted a prospective screening of anti-S1/S2 IgGs against SARS-CoV-2 Spike protein from March, 1 2020 to May, 15 2021 (prior to the vaccination campaign) in a cohort of 713 kidney transplant recipients (KTRs). In a first phase, the factual incidence and seroprevalence of COVID-19 was established in this cohort: cases diagnosed by serology were added to RT-PCR-based diagnoses to obtain the overall incidence of COVID-19 in both symptomatic and asymptomatic KTRs. In the second phase, the kinetics of the post-COVID-19 humoral response were studied, taking into account the severity of the disease defined by the need for oxygen therapy (group S, "severe") or not (group nS, "not severe"). Results: The combined diagnostic approaches identified 138 COVID-19 cases (19.2%), with 37 diagnoses by serology (26.8%). The rate of asymptomatic KTRs reached 20.3% (28/138). Thirteen patients (9.4%) died from COVID-19. The seroconversion rate was 91.7% (99/108). The peak anti-S1/S2 IgG level was 85 [30-150] AU/ml and was similar between the S and nS groups (117 [38; 186] AU/ml versus 73 [23; 140] AU/ml). A high probability of persistence of anti-S1/S2 IgG post-COVID-19 was observed, with only 10.1% (7/69) of the patients having negated their serology during the 9-month follow-up. Conclusion: Our pragmatic serological screening combined with RT-PCR tests provides a better estimation of the real incidence of COVID-19 in KTRs. A significant proportion of KTRs develop humoral immunity post COVID-19, which most often persists beyond 9 months.
Databáze:	MEDLINE
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