Associations Between Intrathecal Levels of Vitamin D, Cytokines, and Core Biomarkers of Alzheimer's Disease: A Cross-Sectional Study.

Autor:	Soares JZ; Medical Department, Section of Geriatrics, Lovisenberg Diaconal Hospital, Oslo, Norway.; Faculty of Medicine, University of Oslo, Oslo, Norway.; Unger-Vetlesen Institute, Lovisenberg Diaconal Hospital, Oslo, Norway., Valeur J; Unger-Vetlesen Institute, Lovisenberg Diaconal Hospital, Oslo, Norway., Šaltytė Benth J; Institute of Clinical Medicine, Campus Ahus, University of Oslo, Oslo, Norway.; Health Services Research Unit, Akershus University Hospital, Lørenskog, Norway., Knapskog AB; Department of Geriatric Medicine, Oslo University Hospital, Oslo, Norway., Selbæk G; Faculty of Medicine, University of Oslo, Oslo, Norway.; Department of Geriatric Medicine, Oslo University Hospital, Oslo, Norway.; Norwegian National Advisory Unit on Ageing and Health, Vestfold Hospital Trust, Tønsberg, Norway., Bogdanovic N; Department of Geriatric Medicine, Oslo University Hospital, Oslo, Norway.; Department for Neurobiology, Caring Science and Society, Division of Clinical Geriatrics, Karolinska Institutet, Stockholm, Sweden., Pettersen R; Medical Department, Section of Geriatrics, Lovisenberg Diaconal Hospital, Oslo, Norway.
Jazyk:	angličtina
Zdroj:	Journal of Alzheimer's disease : JAD [J Alzheimers Dis] 2022; Vol. 89 (3), pp. 825-834.
DOI:	10.3233/JAD-220407
Abstrakt:	Background: Several studies have examined association between vitamin D levels in serum and cognition, but little is known of vitamin D levels in cerebrospinal fluid (CSF) and association with Alzheimer's disease (AD). Objective: In this cross-sectional, explorative study we investigated possible associations of vitamin D in CSF with biomarkers for AD, amyloid-β, tau protein/phosphorylated tau protein in CSF, and with the cytokines IL-6, IL-8, and TNF-α in CSF in patients with cognitive impairment and cognitively healthy controls. Methods: We included 100 outpatients ≥65 years referred for assessment of cognitive impairment and 76 age- and sex-matched cognitively healthy controls. Levels of 25-hydroxyvitamin D (25(OH)D), amyloid-β, tau protein and phosphorylated tau protein, as well as IL-6, IL-8, and TNF-α, were analyzed in CSF in both groups. Results: Higher levels of 25(OH)D in CSF in all groups together were associated with lower levels of tau protein (p = 0.01) and phosphorylated tau protein (p = 0.005). We found no association between 25(OH)D levels in CSF and pathological levels of amyloid-β in CSF nor levels of IL-6 or TNF-α in CSF. Higher levels of 25(OH)D in CSF were associated with higher levels of IL-8 in CSF (p = 0.002). However, vitamin D explained only 6% of variance in IL-8. There was no significant difference between the patient groups and the control group regarding the association between 25(OH)D in CSF and any of the three cytokines in CSF. Conclusion: Participants with higher CSF levels of 25(OH)D exhibited reduced CSF levels of tau protein and phosphorylated tau protein.
Databáze:	MEDLINE
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