Identification of Prognostic Metabolomic Biomarkers at the Interface of Mortality and Morbidity in Pre-Existing TB Cases Infected With SARS-CoV-2.

Autor:	Diboun I; Medical and Population Genomics Lab, Sidra Medicine, Doha, Qatar., Cyprian FS; Department of Basic Medical Sciences, College of Medicine, QU Health, Qatar University, Doha, Qatar., Anwardeen NR; Biomedical Research Center (BRC), QU Health, Qatar University, Doha, Qatar., Yassine HM; Biomedical Research Center (BRC), QU Health, Qatar University, Doha, Qatar., Elrayess MA; Biomedical Research Center (BRC), QU Health, Qatar University, Doha, Qatar., Rahmoon SM; Department of Basic Medical Sciences, College of Medicine, QU Health, Qatar University, Doha, Qatar., Sayed SK; Department of Basic Medical Sciences, College of Medicine, QU Health, Qatar University, Doha, Qatar., Schuchardt S; Fraunhofer Institute for Toxicology and Experimental Medicine (ITEM), Hannover, Germany., Khatib M; Department of Basic Medical Sciences, College of Medicine, QU Health, Qatar University, Doha, Qatar., Bansal D; Department of Public Health, Ministry of Public Health, Doha, Qatar., Farag EABA; Department of Public Health, Ministry of Public Health, Doha, Qatar., Emara MM; Department of Basic Medical Sciences, College of Medicine, QU Health, Qatar University, Doha, Qatar., Abdallah AM; Department of Basic Medical Sciences, College of Medicine, QU Health, Qatar University, Doha, Qatar.
Jazyk:	angličtina
Zdroj:	Frontiers in cellular and infection microbiology [Front Cell Infect Microbiol] 2022 Jul 22; Vol. 12, pp. 929689. Date of Electronic Publication: 2022 Jul 22 (Print Publication: 2022).
DOI:	10.3389/fcimb.2022.929689
Abstrakt:	Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection currently remains one of the biggest global challenges that can lead to acute respiratory distress syndrome (CARDS) in severe cases. In line with this, prior pulmonary tuberculosis (TB) is a risk factor for long-term respiratory impairment. Post-TB lung dysfunction often goes unrecognized, despite its relatively high prevalence and its association with reduced quality of life. In this study, we used a metabolomics analysis to identify potential biomarkers that aid in the prognosis of COVID-19 morbidity and mortality in post-TB infected patients. This analysis involved blood samples from 155 SARS-CoV-2 infected adults, of which 23 had a previous diagnosis of TB (post-TB), while 132 did not have a prior or current TB infection. Our analysis indicated that the vast majority (~92%) of post-TB individuals showed severe SARS-CoV-2 infection, required intensive oxygen support with a significantly high mortality rate (52.2%). Amongst individuals with severe COVID-19 symptoms, we report a significant decline in the levels of amino acids, notably the branched chains amino acids (BCAAs), more so in the post-TB cohort (FDR <= 0.05) in comparison to mild and asymptomatic cases. Indeed, we identified betaine and BCAAs as potential prognostic metabolic biomarkers of severity and mortality, respectively, in COVID-19 patients who have been exposed to TB. Moreover, we identified serum alanine as an important metabolite at the interface of severity and mortality. Hence, our data associated COVID-19 mortality and morbidity with a long-term metabolically driven consequence of TB infection. In summary, our study provides evidence for a higher mortality rate among COVID-19 infection patients who have history of prior TB infection diagnosis, which mandates validation in larger population cohorts. Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (Copyright © 2022 Diboun, Cyprian, Anwardeen, Yassine, Elrayess, Rahmoon, Sayed, Schuchardt, Khatib, Bansal, Farag, Emara and Abdallah.)
Databáze:	MEDLINE
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