Looking Back on 50 Years of Literature to Understand the Potential Impact of Influenza on Extrapulmonary Medical Outcomes.

Autor: Nealon J; Sanofi, Lyon, France., Derqui N; Sanofi, Lyon, France., de Courville C; Sanofi, Lyon, France., Biering-Sørensen T; Department of Cardiology, Copenhagen University Hospital-Herlev and Gentofte, Copenhagen, Denmark., Cowling BJ; School of Public Health, University of Hong Kong, Hong Kong Special Administrative Region, China., Nair H; Usher Institute, University of Edinburgh, Edinburgh, United Kingdom., Chaves SS; Sanofi, Lyon, France.
Jazyk: angličtina
Zdroj: Open forum infectious diseases [Open Forum Infect Dis] 2022 Jul 21; Vol. 9 (8), pp. ofac352. Date of Electronic Publication: 2022 Jul 21 (Print Publication: 2022).
DOI: 10.1093/ofid/ofac352
Abstrakt: We conducted a scoping review of the epidemiological literature from the past 50 years to document the contribution of influenza virus infection to extrapulmonary clinical outcomes. We identified 99 publications reporting 243 associations using many study designs, exposure and outcome definitions, and methods. Laboratory confirmation of influenza was used in only 28 (12%) estimates, mostly in case-control and self-controlled case series study designs. We identified 50 individual clinical conditions associated with influenza. The most numerous estimates were of cardiocirculatory diseases, neurological/neuromuscular diseases, and fetal/newborn disorders, with myocardial infarction the most common individual outcome. Due to heterogeneity, we could not generate summary estimates of effect size, but of 130 relative effect estimates, 105 (81%) indicated an elevated risk of extrapulmonary outcome with influenza exposure. The literature is indicative of systemic complications of influenza virus infection, the requirement for more effective influenza control, and a need for robust confirmatory studies.
(© The Author(s) 2022. Published by Oxford University Press on behalf of Infectious Diseases Society of America.)
Databáze: MEDLINE
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