NMR Spectroscopy-Based Metabolomics of Platelets to Analyze Brain Tumors.

Autor: Pudakalakatti S; Department of Cancer Systems Imaging, The University of Texas MD Anderson Cancer Center, Houston, TX 77054, USA., Audia A; Department of Translational Molecular Pathology, The University of Texas MD Anderson Center Center, Houston, TX 77030, USA., Mukhopadhyay A; Department of Cancer Systems Imaging, The University of Texas MD Anderson Cancer Center, Houston, TX 77054, USA., Enriquez JS; Department of Cancer Systems Imaging, The University of Texas MD Anderson Cancer Center, Houston, TX 77054, USA.; MD Anderson Cancer Center UTHealth Graduate School of Biomedical Sciences, Houston, TX 77054, USA., Bourgeois D; Department of Statistics, Rice University, Houston, TX 77005, USA., Tayob N; Department of Biostatistics, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA., Zacharias NM; MD Anderson Cancer Center UTHealth Graduate School of Biomedical Sciences, Houston, TX 77054, USA.; Department of Urology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA., Millward SW; Department of Cancer Systems Imaging, The University of Texas MD Anderson Cancer Center, Houston, TX 77054, USA.; MD Anderson Cancer Center UTHealth Graduate School of Biomedical Sciences, Houston, TX 77054, USA., Carson D; Department of BioSciences, Rice University, Houston, TX 77005, USA., Farach-Carson MC; MD Anderson Cancer Center UTHealth Graduate School of Biomedical Sciences, Houston, TX 77054, USA.; Department of Diagnostic and Biomedical Sciences, School of Dentistry, The University of Texas Health Science Center, Houston, TX 77054, USA., Lang FF; MD Anderson Cancer Center UTHealth Graduate School of Biomedical Sciences, Houston, TX 77054, USA.; Department of Neurosurgery, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA., Heimberger AB; MD Anderson Cancer Center UTHealth Graduate School of Biomedical Sciences, Houston, TX 77054, USA.; Department of Neurosurgery, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA., Bhat KP; Department of Translational Molecular Pathology, The University of Texas MD Anderson Center Center, Houston, TX 77030, USA.; MD Anderson Cancer Center UTHealth Graduate School of Biomedical Sciences, Houston, TX 77054, USA., Bhattacharya PK; Department of Cancer Systems Imaging, The University of Texas MD Anderson Cancer Center, Houston, TX 77054, USA.; MD Anderson Cancer Center UTHealth Graduate School of Biomedical Sciences, Houston, TX 77054, USA.
Jazyk: angličtina
Zdroj: Reports (MDPI) [Reports (MDPI)] 2021 Dec; Vol. 4 (4). Date of Electronic Publication: 2021 Oct 01.
DOI: 10.3390/reports4040032
Abstrakt: "Tumor-educated platelets" have recently generated substantial interest for the diagnosis of cancer. We hypothesized that tumor educated platelets from patients with brain tumors will reflect altered metabolism compared to platelets from healthy volunteers. Here, in a pilot study, we have employed nuclear magnetic resonance (NMR) spectroscopy in platelets from brain tumor patients to demonstrate altered metabolism compared to the platelets obtained from healthy volunteers.
Competing Interests: Conflicts of Interest: The authors do not have any conflict of interest to report.
Databáze: MEDLINE
Externí odkaz: