Diverse geroprotectors differently affect a mechanism linking cellular aging to cellular quiescence in budding yeast.
Autor: | Leonov A; Department of Biology, Concordia University, Montreal, Quebec H4B 1R6, Canada., Feldman R; Department of Biology, Concordia University, Montreal, Quebec H4B 1R6, Canada., Piano A; Department of Biology, Concordia University, Montreal, Quebec H4B 1R6, Canada., Arlia-Ciommo A; Department of Biology, Concordia University, Montreal, Quebec H4B 1R6, Canada., Junio JAB; Department of Biology, Concordia University, Montreal, Quebec H4B 1R6, Canada., Orfanos E; Department of Biology, Concordia University, Montreal, Quebec H4B 1R6, Canada., Tafakori T; Department of Biology, Concordia University, Montreal, Quebec H4B 1R6, Canada., Lutchman V; Department of Biology, Concordia University, Montreal, Quebec H4B 1R6, Canada., Mohammad K; Department of Biology, Concordia University, Montreal, Quebec H4B 1R6, Canada., Elsaser S; Department of Biology, Concordia University, Montreal, Quebec H4B 1R6, Canada., Orfali S; Department of Biology, Concordia University, Montreal, Quebec H4B 1R6, Canada., Rajen H; Department of Biology, Concordia University, Montreal, Quebec H4B 1R6, Canada., Titorenko VI; Department of Biology, Concordia University, Montreal, Quebec H4B 1R6, Canada. |
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Jazyk: | angličtina |
Zdroj: | Oncotarget [Oncotarget] 2022 Jul 28; Vol. 13, pp. 918-943. Date of Electronic Publication: 2022 Jul 28 (Print Publication: 2022). |
DOI: | 10.18632/oncotarget.28256 |
Abstrakt: | We propose a hypothesis of a mechanism linking cellular aging to cellular quiescence in chronologically aging budding yeast. Our hypothesis posits that this mechanism integrates four different processes, all of which are initiated after yeast cells cultured in a medium initially containing glucose consume it. Quiescent cells that develop in these cultures can be separated into the high- and low-density sub-populations of different buoyant densities. Process 1 of the proposed mechanism consists of a cell-cycle arrest in the G Competing Interests: CONFLICTS OF INTEREST The authors have no conflict of interests to declare. (Copyright: © 2022 Leonov et al.) |
Databáze: | MEDLINE |
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