Influence of smoking history on the evolution of hospitalized in COVID-19 positive patients: Results from the SEMI-COVID-19 registry.

Autor: Navas Alcántara MS; Servicio de Medicina Interna, Hospital Infanta Margarita, Cabra, Córdoba, Spain., Montero Rivas L; Servicio de Medicina Interna, Hospital Infanta Margarita, Cabra, Córdoba, Spain., Guisado Espartero ME; Servicio de Medicina Interna, Hospital Infanta Margarita, Cabra, Córdoba, Spain., Rubio-Rivas M; Servicio de Medicina Interna, Hospital Universitario de Bellvitge, L'Hospitalet de Llobregat (Barcelona), Barcelona, Spain., Ayuso García B; Servicio de Medicina Interna, Hospital Universitario 12 de Octubre, Madrid, Spain., Moreno Martinez F; Servicio de Medicina Interna del Hospital Costa del Sol, Marbella, Málaga, Spain., Ausín García C; Servicio de Medicina Interna, Hospital Gregorio Marañón, Madrid, Spain., Taboada Martínez ML; Servicio de Medicina Interna, Hospital de Cabueñes, Gijón, Asturias, Spain., Arnalich Fernández F; Servicio de Medicina Interna, Hospital Universitario La Paz/Carlos III/Cantoblanco, Madrid, Spain., Martínez Murgui R; Servicio de Medicina Interna, Hospital Royo Villanova, Zaragoza, Spain., Molinos Castro S; Servicio de Medicina Interna, Hospital Clínico de Santiago de Compostela, A Coruña, Spain., Ramos Muñoz ME; Servicio de Medicina Interna, Hospital Clínico San Carlos, Madrid, Spain., Fernández-Garcés M; Servicio de Medicina Interna, H. Universitario Dr. Peset, Valencia, Spain., Carreño Hernandez MC; Unidad de Riesgo Vascular, Servicio de Neumologia, Hospital Madrid Norte Sanchinarro, Hospital Universitario Puerta de Hierro, Majadahonda, Madrid, Spain., García García GM; Servicio de Medicina Interna, Complejo Hospitalario Universitario de Badajoz, Badajoz, Spain., Vázquez Piqueras N; Servicio de Medicina Interna, Hospital Moisès Broggi, Sant Joan Despí, Barcelona, Spain., Abadía-Otero J; Consulta de Enfermedades Infecciosas, Servicio de Medicina Interna, Hospital Universitario Río Hortega, Valladolid, Spain., Lajara Villar L; Servicio de Medicina Interna, Hospital Universitario San Juan de Alicante, Alicante, Spain., Salazar Monteiro C; Servicio de Medicina Interna, Hospital Nuestra Señora del Prado, Talavera de la Reina, Toledo, Spain., Pascual Pérez MLR; Servicio de Medicina Interna, Hospital General Universitario de Elda, Alicante, Spain., Perez-Martin S; Servicio de Medicina Interna, Hospital Marina Baixa, Villajoyosa, Alicante, Spain., Collado-Aliaga J; Servicio de Medicina Interna, Complejo Asistencial Universitario de Salamanca, Spain., Antón-Santos JM; Servicio de Medicina Interna, Hospital Universitario Infanta Cristina, Parla, Madrid, Spain., Lumbreras-Bermejo C; Servicio de Medicina Interna, Hospital Universitario 12 de Octubre, Madrid, Spain.
Jazyk: angličtina
Zdroj: Medicina clinica (English ed.) [Med Clin (Engl Ed)] 2022 Sep 09; Vol. 159 (5), pp. 214-223. Date of Electronic Publication: 2022 Aug 01.
DOI: 10.1016/j.medcle.2022.07.010
Abstrakt: Introduction: Smoking can play a key role in SARS-CoV-2 infection and in the course of the disease. Previous studies have conflicting or inconclusive results on the prevalence of smoking and the severity of the coronavirus disease (COVID-19).
Methods: Observational, multicenter, retrospective cohort study of 14,260 patients admitted for COVID-19 in Spanish hospitals between February and September 2020. Their clinical characteristics were recorded and the patients were classified into a smoking group (active or former smokers) or a non-smoking group (never smokers). The patients were followed up to one month after discharge. Differences between groups were analysed. A multivariate logistic regression and Kapplan Meier curves analysed the relationship between smoking and in-hospital mortality.
Results: The median age was 68.6 (55.8-79.1) years, with 57.7% of males. Smoking patients were older (69.9 (59.6-78.0 years)), more frequently male (80.3%) and with higher Charlson index (4 (2-6)) than non-smoking patients. Smoking patients presented a worse evolution, with a higher rate of admission to the intensive care unit (ICU) (10.4 vs. 8.1%), higher in-hospital mortality (22.5 vs. 16.4%) and readmission at one month (5.8 vs. 4.0%) than in non-smoking patients. After multivariate analysis, smoking remained associated with these events.
Conclusions: Active or past smoking is an independent predictor of poor prognosis in patients with COVID-19. It is associated with higher ICU admissions and in-hospital mortality.
(© 2021 Elsevier España, S.L.U. All rights reserved.)
Databáze: MEDLINE
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