Neurological manifestations by sex and age group in COVID-19 inhospital patients.

Autor:	Pereira DN; Faculdade de Medicina, Universidade Federal de Minas Gerais, Brazil., Bicalho MAC; Faculdade de Medicina, Universidade Federal de Minas Gerais, Brazil.; Fundação Hospitalar do Estado de Minas Gerais (Fhemig), Germany., Jorge AO; Faculdade de Medicina, Universidade Federal de Minas Gerais, Brazil.; Hospital Risoleta Tolentino Neves, Brazil., Gomes AGDR; Hospitais da Rede Mater Dei, Brazil., Schwarzbold AV; Hospital Universitário de Santa Maria/EBSERH; Universidade Federal de Santa Maria, Brazil., Araújo ALH; Hospital Universitário Ciências Médicas, Brazil., Cimini CCR; Hospital Santa Rosália, Brazil.; Universidade Federal dos Vales do Jequitinhonha e Mucuri (UFVJM), Brazil.; Institute for Health Technology Assessment (IATS/ CNPq), Brazil., Ponce D; Hospital das Clínicas da Faculdade de Medicina de Botucatu, Brazil., Rios DRA; Complexo da Saúde São João de Deus, Universidade Federal de São João del-Rei, Brazil.; Campus Centro Oeste Dona Lindu, Universidade Federal de São João del-Rei, Brazil., Grizende GMS; Santa Casa de Misericórdia de Belo Horizonte, Brazil., Manenti ERF; Hospital Mãe de Deus, Brazil., Anschau F; Grupo Hospitalar Conceição, Brazilian National Health System, Hospital Nossa Senhora da Conceição and Hospital Cristo Redentor, Brazil., Aranha FG; Hospital SOS Cárdio, Brasil., Bartolazzi F; Hospital Santo Antônio, Brasil., Batista JDL; Universidade Federal Fronteira do Sul, Brasil.; Instituto de Avaliação de Tecnologia em Saúde (IATS/CNPQ), Brazil.; Hospital Regional do Oeste, Brazil., Tupinambás JT; Hospital Metropolitano Odilon Behrens, Brazil., Ruschel KB; Hospital Mãe de Deus, Hospital Universitário de Canoas, Universidade Federal do Rio Grande do Sul e Instituto de Avaliação de Tecnologia em Saúde (IATS/CNPQ), Brazil., Ferreira MAP; Hospital de Clínicas de Porto Alegre; IATS/CnPq, Brazil., Paraíso PG; Orizonti- Instituto Oncomed de Saúde e Longevidade, Brazil., Araújo SF; Hospital Semper, Brazil., Teixeira AL; Faculdade Santa Casa BH, Brazil.; Neuropsychiatry Program, Department of Psychiatry and Behavioral Sciences, UT Health Houston, Brazil., Marcolino MS; Department of Internal Medicine, Medical School, and Telehealth Center, University Hospital, Universidade Federal de Minas Gerais, Brazil.; Institute for Health Technology Assessment (IATS/ CNPq), Brazil.
Jazyk:	angličtina
Zdroj:	ENeurologicalSci [eNeurologicalSci] 2022 Sep; Vol. 28, pp. 100419. Date of Electronic Publication: 2022 Jul 30.
DOI:	10.1016/j.ensci.2022.100419
Abstrakt:	Introduction: Neurological manifestations have been associated with a poorer prognosis in COVID-19. However, data regarding their incidence according to sex and age groups is still lacking. Methods: This retrospective multicentric cohort collected data from 39 Brazilian hospitals from 17 cities, from adult COVID-19 admitted from March 2020 to January 2022. Neurological manifestations presented at hospital admission were assessed according to incidence by sex and age group. Results: From 13,603 COVID-19 patients, median age was 60 years old and 53.0% were men. Women were more likely to present with headaches (22.4% vs. 17.7%, p  < 0.001; OR 1.36, 95% confidence interval [CI] 1.22-1.52) than men and also presented a lower risk of having seizures (OR 0.43, 95% CI 0.20-0.94). Although delirium was more frequent in women (6.6% vs. 5.7%, p  = 0.020), sex was not associated with delirium in the multivariable logistc regresssion analysis. Delirium, syncope and coma increased with age (1.5% [18-39 years] vs. 22.4% [80 years or over], p < 0.001, OR 1.07, 95% CI 1.06-1.07; 0.7% vs. 1.7%, p  = 0.002, OR 1.01, 95% CI 1.00-1.02; 0.2% vs. 1.3% p < 0.001, OR 1.04, 95% CI 1.02-1.06), while, headache (26.5% vs. 7.1%, OR 0.98, 95% CI 0.98-0.99), anosmia (11.4% vs. 3.3%, OR 0.99, 95% CI] 0.98-0.99 and ageusia (13.1% vs. 3.5%, OR 0.99, CI 0.98-0.99) decreased (p < 0.001 for all). Conclusion: Older COVID-19 patients were more likely to present delirium, syncope and coma, while the incidence of anosmia, ageusia and headaches decreased with age. Women were more likely to present headache, and less likely to present seizures. (© 2022 The Authors.)
Databáze:	MEDLINE
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