The Role of Manganese in Very Low Birth Weight Infants.

Autor: Vetter-Laracy S; From the Division of Neonatology, Department of Pediatrics, University Hospital Son Espases, Palma de Mallorca, Spain.; the Balearic Islands Health Research Institute (IdISBa)., Tejedor M; From the Division of Neonatology, Department of Pediatrics, University Hospital Son Espases, Palma de Mallorca, Spain.; the Balearic Islands Health Research Institute (IdISBa)., Cobo P; From the Division of Neonatology, Department of Pediatrics, University Hospital Son Espases, Palma de Mallorca, Spain.; the Balearic Islands Health Research Institute (IdISBa)., Bauça JM; the Balearic Islands Health Research Institute (IdISBa).; the Department of Laboratory Medicine University Hospital Son Espases, Palma de Mallorca, Spain., Robles J; the Department of Laboratory Medicine University Hospital Son Espases, Palma de Mallorca, Spain., Ortiz-Montero R; the Department of Laboratory Medicine University Hospital Son Espases, Palma de Mallorca, Spain., Pastor A; the Department of Laboratory Medicine University Hospital Son Espases, Palma de Mallorca, Spain., Beltrán E; From the Division of Neonatology, Department of Pediatrics, University Hospital Son Espases, Palma de Mallorca, Spain.; the Balearic Islands Health Research Institute (IdISBa).
Jazyk: angličtina
Zdroj: Journal of pediatric gastroenterology and nutrition [J Pediatr Gastroenterol Nutr] 2022 Nov 01; Vol. 75 (5), pp. e98-e105. Date of Electronic Publication: 2022 Aug 03.
DOI: 10.1097/MPG.0000000000003582
Abstrakt: Objectives: High manganese (Mn) levels during fetal growth or prolonged parenteral nutrition (PN) may have adverse effects on neurodevelopment. We aim to report on Mn levels and their short-term impact on clinical course in very low birth weight infants.
Methods: An observational study including newborns with a gestational age (GA) ≤32 weeks and/or ≤1500 g of birth weight (BW). Newborns received intravenous supplementation of Mn at 1 µg/kg/day (Peditrace ® ) in PN and continued with fortified breast milk. Mothers answered surveys about dietary and other habits and blood levels of Mn in newborns were analyzed at days 1, 15, and 30 of life. Associations of Mn levels with mothers' and newborns' data were evaluated and adjusted for multiple comparisons.
Results: One hundred and sixty premature infants were recruited. Median blood Mn levels at birth were 43.0 and 24.5 µg/L at day 30. No important association with mothers' data was found. Median [interquartile range (IQR)] duration of PN was 8 days (7-14). A prolonged PN and late oral feeding showed a nonsignificant association with lower blood Mn levels at day 30 ( P = 0.010, P threshold 0.003). Mn levels at day 15 and 30 were associated with increasing GA ( P < 0.001). Low Mn was not a significant predictor of adverse outcomes such as retinopathy of prematurity, bronchopulmonary dysplasia, or respiratory distress syndrome after adjusting for potential confounders and multiple testing.
Conclusions: Mn showed lower levels with decreasing GA and prolonged PN. Using a low Mn PN solution may not raise blood Mn levels in premature infants.
Competing Interests: S.V.-L., M.T., P.C., J.M.B., and E.B. are the members of the Fundació Institut d’Investigació Sanitària Illes Balears – IdISBa. The remaining authors report no conflicts of interest.
(Copyright © 2022 by European Society for European Society for Pediatric Gastroenterology, Hepatology, and Nutrition and North American Society for Pediatric Gastroenterology, Hepatology, and Nutrition.)
Databáze: MEDLINE
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