Outcomes of Debridement, Antibiotics and Implant Retention (DAIR) for Periprosthetic Joint Infection in a High-Volume Arthroplasty Centre.

Autor: Walkay S; Department of Orthopaedics, Golden Jubilee National Hospital, Clydebank, Glasgow, Scotland, UK., Wallace DT; Department of Orthopaedics, Golden Jubilee National Hospital, Clydebank, Glasgow, Scotland, UK., Balasubramaniam VSC; Department of Orthopaedics, Golden Jubilee National Hospital, Clydebank, Glasgow, Scotland, UK., Maheshwari R; Department of Orthopaedics, Golden Jubilee National Hospital, Clydebank, Glasgow, Scotland, UK., Changulani M; Department of Orthopaedics, Golden Jubilee National Hospital, Clydebank, Glasgow, Scotland, UK., Sarungi M; Department of Orthopaedics, Golden Jubilee National Hospital, Clydebank, Glasgow, Scotland, UK.
Jazyk: angličtina
Zdroj: Indian journal of orthopaedics [Indian J Orthop] 2022 May 28; Vol. 56 (8), pp. 1449-1456. Date of Electronic Publication: 2022 May 28 (Print Publication: 2022).
DOI: 10.1007/s43465-022-00655-y
Abstrakt: Purpose: Prosthetic joint infection (PJI) following total knee arthroplasty (TKA) and total hip arthroplasty (THA) can be a devastating diagnosis. Debridement, antibiotics and implant retention (DAIR) is a preferred treatment modality for acute PJI. A retrospective analysis of infected primary arthroplasties to evaluate the success of DAIR and factors influencing its outcomes.
Methods: We retrospectively reviewed all patients who underwent DAIR for PJI at our unit between 2010 and 2018. Patients who underwent revision surgery as an index procedure, arthroscopic washout and those with less than two years of follow-up were excluded. Treatment failure was defined as revision arthroplasty for recurrence of infection within 2 years of the index procedure. Chi-square and Fischer's exact test were used to compare between patient factors and DAIR outcomes. Kaplan-Meier survival curve and log-rank test were used to analyse implant survivorship following DAIR.
Results: Of the sixty patients (40 knees, 20 hips) who underwent DAIR, eighteen (13 knees, 5 hips) required revision arthroplasty within 2 years accounting for a success rate of 70%. Predictive factors for revision were American Society of Anaesthesiologist (ASA) score of greater than 2 ( p  = 0.021), BMI > 35 ( p  = 0.046), C Reactive protein (CRP) > 200 mg/L ( p  = 0.007) and Staphylococcus aureus growth ( p  = 0.012). The five-year survival rate for DAIR was 70%, which remained constant after two years from DAIR.
Conclusion: Success rate of DAIR in PJI was 70% which was comparable to similar studies in the literature. ASA > 2, BMI > 35, CRP > 200 and staphylococcus aureus growth were predictors for DAIR failure. Implant survival rate and duration were better following DAIR in early-onset PJI.
Competing Interests: Conflict of InterestThe authors have no relevant financial or non-financial interests to disclose.
(© Crown 2022.)
Databáze: MEDLINE
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