First Direct Insight into the Local Environment and Dynamics of Water Molecules in the Whewellite Mineral Phase: Mechanochemical Isotopic Enrichment and High-Resolution 17 O and 2 H NMR Analyses.

Autor: Goldberga I; ICGM, Univ Montpellier, CNRS, ENSCM, 34293 Montpellier, France., Patris N; HydroSciences Montpellier, UMR 5151, CNRS, IRD, Université de Montpellier, 34090 Montpellier, France., Chen CH; ICGM, Univ Montpellier, CNRS, ENSCM, 34293 Montpellier, France., Thomassot E; Université de Lorraine, CRPG, CNRS UMR 7358, 54500 Vandœuvre-lès-Nancy, France., Trébosc J; Université de Lille, CNRS, INRAE, Centrale Lille, Université d'Artois FR2638-IMEC-Institut Michel Eugène Chevreul, 59000 Lille, France., Hung I; National High Magnetic Field Laboratory (NHMFL), Tallahassee, Florida 32310, United States., Gan Z; National High Magnetic Field Laboratory (NHMFL), Tallahassee, Florida 32310, United States., Berthomieu D; ICGM, Univ Montpellier, CNRS, ENSCM, 34293 Montpellier, France., Métro TX; IBMM, Univ Montpellier, CNRS, ENSCM, 34293 Montpellier, France., Bonhomme C; LCMCP, UMR 7574, Sorbonne Université, CNRS, 75005 Paris, France., Gervais C; LCMCP, UMR 7574, Sorbonne Université, CNRS, 75005 Paris, France., Laurencin D; ICGM, Univ Montpellier, CNRS, ENSCM, 34293 Montpellier, France.
Jazyk: angličtina
Zdroj: The journal of physical chemistry. C, Nanomaterials and interfaces [J Phys Chem C Nanomater Interfaces] 2022 Jul 28; Vol. 126 (29), pp. 12044-12059. Date of Electronic Publication: 2022 Jul 19.
DOI: 10.1021/acs.jpcc.2c02070
Abstrakt: Calcium oxalate minerals of the general formula CaC 2 O 4 . x H 2 O are widely present in nature and usually associated with pathological calcifications, constituting up to 70-80% of the mineral component of renal calculi. The monohydrate phase (CaC 2 O 4 . H 2 O, COM) is the most stable form, accounting for the majority of the hydrated calcium oxalates found. These mineral phases have been studied extensively via X-ray diffraction and IR spectroscopy and, to a lesser extent, using 1 H, 13 C, and 43 Ca solid-state NMR spectroscopy. However, several aspects of their structure and reactivity are still unclear, such as the evolution from low- to high-temperature COM structures (LT-COM and HT-COM, respectively) and the involvement of water molecules in this phase transition. Here, we report for the first time a 17 O and 2 H solid-state NMR investigation of the local structure and dynamics of water in the COM phase. A new procedure for the selective 17 O- and 2 H-isotopic enrichment of water molecules within the COM mineral is presented using mechanochemistry, which employs only microliter quantities of enriched water and leads to exchange yields up to ∼30%. 17 O NMR allows both crystallographically inequivalent water molecules in the LT-COM structure to be resolved, while 2 H NMR studies provide unambiguous evidence that these water molecules are undergoing different types of motions at high temperatures without exchanging with one another. Dynamics appear to be essential for water molecules in these structures, which have not been accounted for in previous structural studies on the HT-COM structure due to lack of available tools, highlighting the importance of such NMR investigations for refining the overall knowledge on biologically relevant minerals like calcium oxalates.
Competing Interests: The authors declare no competing financial interest.
(© 2022 The Authors. Published by American Chemical Society.)
Databáze: MEDLINE
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