Impact of different COVID-19 waves on kidney replacement therapy epidemiology and mortality: REMER 2020.

Autor:	Carriazo S; Department of Nephrology and Hypertension, IIS-Fundacion Jimenez Diaz, Madrid, Spain.; RICORS2040, Madrid, Spain., Aparicio-Madre MI; REMER, Oficina Regional de Coordinación de Trasplantes de la Comunidad de Madrid, Madrid, Spain., Tornero-Molina F; Department of Nephrology, Hospital del Sureste, Madrid, Spain., Fernández-Lucas M; Department of Nephrology, Hospital Universitario Ramón y Cajal, Universidad de Alcalá, Madrid, Spain., Paraiso-Cuevas V; Department of Nephrology, Hospital del Henares, Madrid, Spain., González-Parra E; Department of Nephrology and Hypertension, IIS-Fundacion Jimenez Diaz, Madrid, Spain.; RICORS2040, Madrid, Spain.; Departamento de Medicina, Facultad de Medicina, Universidad Autónoma de Madrid, Madrid, Spain., Del Río-Gallegos F; REMER, Oficina Regional de Coordinación de Trasplantes de la Comunidad de Madrid, Madrid, Spain., Marques-Vidas M; Departamento de Medicina, Facultad de Medicina, Universidad Autónoma de Madrid, Madrid, Spain.; Department of Nephrology, Hospital Puerta de Hierro, Madrid, Spain., Alcázar-Arroyo R; Department of Nephrology, Hospital Infanta Leonor, Madrid, Spain., Martins-Muñoz J; Department of Nephrology, Hospital de Getafe, Madrid, Spain., Sánchez-Villanueva R; Department of Nephrology, Hospital La Paz, Madrid, Spain., Gil-Casares B; Department of Nephrology, Hospital del Sureste, Madrid, Spain., Gutiérrez-Martínez E; Department of Nephrology, Hospital 12 de Octubre, Madrid, Spain., Martínez-Rubio MP; Centro de Diálisis El Pilar, Madrid, Spain., Ortiz A; Department of Nephrology and Hypertension, IIS-Fundacion Jimenez Diaz, Madrid, Spain.; RICORS2040, Madrid, Spain.; Departamento de Medicina, Facultad de Medicina, Universidad Autónoma de Madrid, Madrid, Spain.
Jazyk:	angličtina
Zdroj:	Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association [Nephrol Dial Transplant] 2022 Oct 19; Vol. 37 (11), pp. 2253-2263.
DOI:	10.1093/ndt/gfac234
Abstrakt:	Background: Kidney replacement therapy (KRT) confers the highest risk of death from coronavirus disease 2019 (COVID-19). However, most data refer to the early pandemic waves. Whole-year analysis compared with prior secular trends are scarce. Methods: We present the 2020 REMER Madrid KRT registry, corresponding to the Spanish Region hardest hit by COVID-19. Results: In 2020, KRT incidence decreased 12% versus 2019, while KRT prevalence decreased by 1.75% for the first time since records began and the number of kidney transplants (KTs) decreased by 16%. Mortality on KRT was 10.2% (34% higher than the mean for 2008-2019). The 2019-2020 increase in mortality was larger for KTs (+68%) than for haemodialysis (+24%) or peritoneal dialysis (+38%). The most common cause of death was infection [n = 419 (48% of deaths)], followed by cardiovascular [n = 200 (23%)]. Deaths from infection increased by 167% year over year and accounted for 95% of excess deaths in 2020 over 2019. COVID-19 was the most common cause of death (68% of infection deaths, 33% of total deaths). The bulk of COVID-19 deaths [209/285 (73%)] occurred during the first COVID-19 wave, which roughly accounted for the increased mortality in 2020. Being a KT recipient was an independent risk factor for COVID-19 death. Conclusions: COVID-19 negatively impacted the incidence and prevalence of KRT, but the increase in KRT deaths was localized to the first wave of the pandemic. The increased annual mortality argues against COVID-19 accelerating the death of patients with short life expectancy and the temporal pattern of COVID-19 mortality suggests that appropriate healthcare may improve outcomes. (© The Author(s) 2022. Published by Oxford University Press on behalf of the ERA.)
Databáze:	MEDLINE
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