Blind cavefish retain functional connectivity in the tectum despite loss of retinal input.

Autor:	Lloyd E; Department of Biological Science, Florida Atlantic University, Jupiter, FL 33458, USA; Department of Biology, Texas A&M University, College Station, TX 77843, USA; Harriet Wilkes Honors College, Florida Atlantic University, Jupiter, FL 33458, USA., McDole B; Department of Biological Science, Florida Atlantic University, Jupiter, FL 33458, USA., Privat M; Institut de Biologie de l'ENS (IBENS), Département de Biologie, École Normale Supérieure, CNRS, INSERM, Université PSL, 75005 Paris, France., Jaggard JB; Department of Biological Science, Florida Atlantic University, Jupiter, FL 33458, USA; Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, CA 94305, USA., Duboué ER; Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, CA 94305, USA., Sumbre G; Institut de Biologie de l'ENS (IBENS), Département de Biologie, École Normale Supérieure, CNRS, INSERM, Université PSL, 75005 Paris, France. Electronic address: sumbre@bio.ens.psl.eu., Keene AC; Department of Biology, Texas A&M University, College Station, TX 77843, USA. Electronic address: akeene@bio.tamu.edu.
Jazyk:	angličtina
Zdroj:	Current biology : CB [Curr Biol] 2022 Sep 12; Vol. 32 (17), pp. 3720-3730.e3. Date of Electronic Publication: 2022 Aug 04.
DOI:	10.1016/j.cub.2022.07.015
Abstrakt:	Sensory systems display remarkable plasticity and are under strong evolutionary selection. The Mexican cavefish, Astyanax mexicanus, consists of eyed river-dwelling surface populations and multiple independent cave populations that have converged on eye loss, providing the opportunity to examine the evolution of sensory circuits in response to environmental perturbation. Functional analysis across multiple transgenic populations expressing GCaMP6s showed that functional connectivity of the optic tectum largely did not differ between populations, except for the selective loss of negatively correlated activity within the cavefish tectum, suggesting positively correlated neural activity is resistant to an evolved loss of input from the retina. Furthermore, analysis of surface-cave hybrid fish reveals that changes in the tectum are genetically distinct from those encoding eye loss. Together, these findings uncover the independent evolution of multiple components of the visual system and establish the use of functional imaging in A. mexicanus to study neural circuit evolution. Competing Interests: Declaration of interests The authors declare no competing interests. (Copyright © 2022 The Authors. Published by Elsevier Inc. All rights reserved.)
Databáze:	MEDLINE
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