Antiglycation, antioxidant and cytotoxicity activities of crude extract of Turnera ulmifolia L. before and after microencapsulation process.

Autor: Viel AM; São Paulo State University (UNESP), Institute of Chemistry, Araraquara, São Paulo, Brazil., Figueiredo CCM; São Paulo State University (UNESP), Institute of Chemistry, Araraquara, São Paulo, Brazil., Granero FO; São Paulo State University (UNESP), Institute of Chemistry, Araraquara, São Paulo, Brazil., Silva LP; Fundação Educacional do Município de Assis (FEMA), Assis, São Paulo, Brazil., Ximenes VF; São Paulo State University (UNESP), School of Sciences, Department of Chemistry, Bauru, Brazil., Godoy TM; Federal University of Rio de Janeiro (UFRJ), Institute of Biomedical Sciences, Laboratory of Biochemical and Molecular Pharmacology, Rio de Janeiro, Brazil., Quintas LEM; Federal University of Rio de Janeiro (UFRJ), Institute of Biomedical Sciences, Laboratory of Biochemical and Molecular Pharmacology, Rio de Janeiro, Brazil., Silva RMGD; São Paulo State University (UNESP), Institute of Chemistry, Araraquara, São Paulo, Brazil; São Paulo State University (UNESP), School of Sciences, Humanities and Languages, Department of Biotechnology, Laboratory of Phytotherapic and Natural Products, Assis, São Paulo, Brazil. Electronic address: regildo.silva@unesp.br.
Jazyk: angličtina
Zdroj: Journal of pharmaceutical and biomedical analysis [J Pharm Biomed Anal] 2022 Sep 20; Vol. 219, pp. 114975. Date of Electronic Publication: 2022 Jul 29.
DOI: 10.1016/j.jpba.2022.114975
Abstrakt: Turnera ulmifolia L. is used in folk medicine and it is known to have anti-hyperglycemic effect on the organism in order to reduce complications in diabetic patients. Glycation process is directly related to oxidative stress, acting as an important endogenous source, inducing the production of free radicals, and thus increasing the production of reactive oxygen species. The encapsulation technology on natural compounds can minimize and even mitigate the risk of loss of biological activity in order to maintain their activities against oxidative stress and glycation. The present study aimed to evaluate the antiglycation and antioxidant activities of T. ulmifolia extract before and after encapsulation and cytotoxicity of the crude extract. This study presents important information about the biological activities, highlighting antioxidant and antiglycation potential and no cytotoxicity of Turnera ulmifolia crude extract, a species of genus Turnera that has been poorly studied. T. ulmifolia crude extract presented flavonoids as main active compounds. The results showed a promising activity in scavenging free and peroxyl radicals, chelating iron ions and inhibiting BSA glycation. In addition, this study showed the possible encapsulation of bioactive compounds using maltodextrin as wall material.
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Databáze: MEDLINE
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