Serum Immunoglobulin E and Vitamin D Levels in Asthma Patients in Enugu, Nigeria: Association with Asthma Control.

Autor:	Ibegbu MD; Department of Medical Biochemistry, Faculty of Basic Medical Sciences, College of Medicine, University of Nigeria, Enugu Campus, Nigeria., Ebulue CE; Department of Medical Biochemistry, Faculty of Basic Medical Sciences, College of Medicine, University of Nigeria, Enugu Campus, Nigeria., Eze JN; Department of Paediatrics, Faculty of Medical Sciences, College of Medicine, University of Nigeria, Enugu State, Nigeria., Ndubuisi CA; Department of Medical Biochemistry, Faculty of Basic Medical Sciences, College of Medicine, University of Nigeria, Enugu Campus, Nigeria., Orji OC; Department of Medical Laboratory Sciences, Faculty of Health Sciences, College of Medicine, University of Nigeria, Enugu Campus, Nigeria., Ikekpeazu JE; Department of Medical Biochemistry, Faculty of Basic Medical Sciences, College of Medicine, University of Nigeria, Enugu Campus, Nigeria., Onyedum CC; Department of Medicine, Faculty of Medical Sciences, College of Medicine, University of Nigeria, Enugu State, Nigeria.
Jazyk:	angličtina
Zdroj:	West African journal of medicine [West Afr J Med] 2022 Jul 31; Vol. 39 (7), pp. 721-728.
Abstrakt:	Background: Asthma symptoms are often mediated by changes in immune responses to allergens measured by the levels of immunoglobulin E (IgE) and non-protein regulators such as 25-hydroxycholecalciferol (25 (OH) vitamin D3). The relationship between serum levels of IgE, 25 (OH) Vitamin D3, and asthma control in asthma patients remains unclear. Objective: To measure the serum IgE and 25 (OH) vitamin D3 levels in asthma patients and determine their relationship with patient's asthma control. Methods: This was a cross-sectional study of children and adults with asthma aged 5 to 60 years old; and their controls seen in a tertiary hospital in Enugu, south eastern Nigeria from October 2018 to January 2019. Serum levels of IgE, and 25 (OH) vitamin D3 were determined by sandwich enzyme-linked immunosorbent assay (ELISA); and compared between groups using the Student's t-tests. Association between IgE, 25 (OH) vitamin D3 levels, and asthma control were determined using the Chi-square. Results: Sixty-five (65) asthma patients and thirty-three (36) non-asthma controls were studied. Mean serum level of IgE (411.32± 220.18 IU/ml) was significantly raised in asthma patients compared to controls (163.51 ± 186.36 lU/ml); p=0.001. There was no significant difference in mean 25 (OH) vitamin D3 levels in asthma (68.55 ± 25.91 ng/ml) compared to controls (77.25 ± 34.01 ng/ml); p=0.153. No significant association was found between patient's asthma control status, and serum IgE and 25 (OH) vitamin D3 levels. Conclusion: Asthma control status was not associated with Immunoglobulin E and 25 (OH) vitamin D3 levels in those studied. More robust study is required to evaluate the relationship between asthma control, IgE and vitamin D levels. Competing Interests: The Authors declare that no competing interest exists. (Copyright © 2022 by West African Journal of Medicine.)
Databáze:	MEDLINE
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