The structure, biosynthesis, and biological roles of fetuin-A: A review.

Autor:	Chekol Abebe E; Department of Medical Biochemistry, College of Health Sciences, Debre Tabor University, Debre Tabor, Ethiopia., Tilahun Muche Z; Department of Physiology, College of Health Sciences, Debre Tabor University, Debre Tabor, Ethiopia., Behaile T/Mariam A; Department of Medical Biochemistry, College of Health Sciences, Debre Tabor University, Debre Tabor, Ethiopia., Mengie Ayele T; Department of Pharmacy, College of Health Sciences, Debre Tabor University, Debre Tabor, Ethiopia., Mekonnen Agidew M; Department of Medical Biochemistry, College of Health Sciences, Debre Tabor University, Debre Tabor, Ethiopia., Teshome Azezew M; Department of Physiology, College of Health Sciences, Debre Tabor University, Debre Tabor, Ethiopia., Abebe Zewde E; Department of Physiology, College of Health Sciences, Debre Tabor University, Debre Tabor, Ethiopia., Asmamaw Dejenie T; Department of Medical Biochemistry, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia., Asmamaw Mengstie M; Department of Medical Biochemistry, College of Health Sciences, Debre Tabor University, Debre Tabor, Ethiopia.
Jazyk:	angličtina
Zdroj:	Frontiers in cell and developmental biology [Front Cell Dev Biol] 2022 Jul 18; Vol. 10, pp. 945287. Date of Electronic Publication: 2022 Jul 18 (Print Publication: 2022).
DOI:	10.3389/fcell.2022.945287
Abstrakt:	Fetuin-A is a heterodimeric plasma glycoprotein containing an A-chain of 282 amino acids and a B-chain of 27 amino acid residues linked by a single inter-disulfide bond. It is predominantly expressed in embryonic cells and adult hepatocytes, and to a lesser extent in adipocytes and monocytes. Fetuin-A binds with a plethora of receptors and exhibits multifaceted physiological and pathological functions. It is involved in the regulation of calcium metabolism, osteogenesis, and the insulin signaling pathway. It also acts as an ectopic calcification inhibitor, protease inhibitor, inflammatory mediator, anti-inflammatory partner, atherogenic factor, and adipogenic factor, among other several moonlighting functions. Fetuin-A has also been demonstrated to play a crucial role in the pathogenesis of several disorders. This review mainly focuses on the structure, synthesis, and biological roles of fetuin-A. Information was gathered manually from various journals via electronic searches using PubMed, Google Scholar, HINARI, and Cochrane Library from inception to 2022. Studies written in English and cohort, case-control, cross-sectional, or experimental studies were considered in the review, otherwise excluded. Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (Copyright © 2022 Chekol Abebe, Tilahun Muche, Behaile T/Mariam, Mengie Ayele, Mekonnen Agidew, Teshome Azezew, Abebe Zewde, Asmamaw Dejenie and Asmamaw Mengstie.)
Databáze:	MEDLINE
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