Changes to lung surfactant monolayers upon exposure to gas phase ozone observed using X-ray and neutron reflectivity.

Autor:	Hemming JM; Institute of Structural and Molecular Biology, Department of Biological Sciences, Birkbeck, University of London Malet Street London WC1E 7HX UK k.thompson@bbk.ac.uk., Szyroka J; Institute of Structural and Molecular Biology, Department of Biological Sciences, Birkbeck, University of London Malet Street London WC1E 7HX UK k.thompson@bbk.ac.uk., Shokano G; Institute of Structural and Molecular Biology, Department of Biological Sciences, Birkbeck, University of London Malet Street London WC1E 7HX UK k.thompson@bbk.ac.uk., Arnold T; European Spallation Source The ESS Campus Lund Sweden SE-221 00.; ISIS Neutron and Muon Source, Science and Technology Facilities Council, Rutherford Appleton Laboratory Harwell, Didcot Oxford OX11 0QX UK.; Department of Chemistry, University of Bath Claverton Down Bath Avon BA2 7AY UK., Skoda MWA; ISIS Neutron and Muon Source, Science and Technology Facilities Council, Rutherford Appleton Laboratory Harwell, Didcot Oxford OX11 0QX UK., Rennie AR; Department of Chemistry - Ångström and Centre for Neutron Scattering, Uppsala University Box 538 75121 Uppsala Sweden., Thompson KC; Institute of Structural and Molecular Biology, Department of Biological Sciences, Birkbeck, University of London Malet Street London WC1E 7HX UK k.thompson@bbk.ac.uk.
Jazyk:	angličtina
Zdroj:	Environmental science: atmospheres [Environ Sci Atmos] 2022 Jun 14; Vol. 2 (4), pp. 753-760. Date of Electronic Publication: 2022 Jun 14 (Print Publication: 2022).
DOI:	10.1039/d2ea00032f
Abstrakt:	Exposure to the secondary pollutant ozone in ambient air is associated with adverse health effects when inhaled. In this work we use surface pressure measurements, combined with X-ray and neutron reflection, to observe changes in a layer of lung surfactant at the air water interface when exposed to gas phase ozone. The results demonstrate that the layer reacts with ozone changing its physical characteristics. A slight loss of material, a significant thinning of the layer and increased hydration of the surfactant material is observed. The results support the hypothesis that unsaturated lipids present in lung surfactant are still susceptible to rapid reaction with ozone and the reaction changes the properties of the interfacial layer. Competing Interests: There are no conflicts to declare. (This journal is © The Royal Society of Chemistry.)
Databáze:	MEDLINE
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