Volume Doubling Time of Pulmonary Carcinoid Tumors Measured by Computed Tomography.

Autor: Russ DH; Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, PA. Electronic address: dhr006@students.jefferson.edu., Barta JA; Division of Pulmonary, Allergy and Critical Care, Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, PA., Evans NR; Division of Thoracic Surgery, Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, PA., Stapp RT; Department of Pathology, Anatomy, and Cell Biology, Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, PA., Kane GC; The Jane and Leonard Korman Respiratory Institute at Thomas Jefferson University, Philadelphia, PA.
Jazyk: angličtina
Zdroj: Clinical lung cancer [Clin Lung Cancer] 2022 Nov; Vol. 23 (7), pp. e453-e459. Date of Electronic Publication: 2022 Jul 01.
DOI: 10.1016/j.cllc.2022.06.006
Abstrakt: Introduction: Pulmonary carcinoid tumor (PCT) is a rare neuroendocrine lung neoplasm comprising approximately 2% of lung cancer diagnoses. It is classified as either localized low-grade (typical) or intermediate-grade (atypical) subtypes. PCT is known clinically to be a slow-growing cancer, however few studies have established its true growth rate when followed over time by computed tomography (CT). Therefore, we sought to determine the volume doubling time for PCTs as visualized on CT imaging.
Materials and Methods: We conducted a retrospective analysis of all PCTs treated at our institution between 2006 and 2020. Nodule dimensions were measured using a Picture Archiving and Communication System or retrieved from radiology reports. Volume doubling time was calculated using the Schwartz formula for PCTs followed by successive CT scans during radiographic surveillance. Consistent with Fleischner Society guidelines, tumors were considered to have demonstrated definitive growth by CT only when the interval change in tumor diameter was greater than or equal to 2 mm.
Results: The median volume doubling time of 13 typical PCTs was 977 days, or 2.7 years. Five atypical PCTs were followed longitudinally, with a median doubling time of 327 days, or 0.9 years.
Conclusions: Typical pulmonary carcinoid features a remarkably slow growth rate as compared to more common lung cancers. Our analysis of atypical pulmonary carcinoid included too few cases to offer definitive conclusions. It is conceivable that clinicians following current nodule surveillance guidelines may mistake incidentally detected typical carcinoids for benign non-growing lesions when followed for less than 2 years in low-risk patients.
(Copyright © 2022 Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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