Biodegradable Polymer Matrix Composites Containing Graphene-Related Materials for Antibacterial Applications: A Critical Review.

Autor: Avcu E; Department of Mechanical Engineering, Natural and Applied Sciences, Kocaeli University, Kocaeli 41001 Turkey; Department of Materials, The University of Manchester, Manchester M13-9PL UK. Electronic address: avcuegemen@gmail.com., Bastan FE; Department of Metallurgy and Materials Engineering, Thermal Spray Research and Development Laboratory, Sakarya University, Sakarya 54187 Turkey; Institute of Biomaterials, University of Erlangen-Nuremberg, Erlangen 91058 Germany., Guney M; The Environment and Resource Efficiency Cluster (EREC), Nazarbayev University, Nur-Sultan 010000 Kazakhstan; Department of Civil and Environmental Engineering, School of Engineering and Digital Sciences, Nazarbayev University, Kabanbay Batyr Ave. 53, Nur-Sultan 010000 Kazakhstan., Yildiran Avcu Y; Department of Mechanical Engineering, Natural and Applied Sciences, Kocaeli University, Kocaeli 41001 Turkey., Ur Rehman MA; Department of Materials Science and Engineering, Institute of Space Technology Islamabad, Islamabad 44000 Pakistan., Boccaccini AR; Institute of Biomaterials, University of Erlangen-Nuremberg, Erlangen 91058 Germany. Electronic address: aldo.boccaccini@fau.de.
Jazyk: angličtina
Zdroj: Acta biomaterialia [Acta Biomater] 2022 Oct 01; Vol. 151, pp. 1-44. Date of Electronic Publication: 2022 Jul 31.
DOI: 10.1016/j.actbio.2022.07.048
Abstrakt: For the first time, the present review critically evaluates biodegradable polymer matrix composites containing graphene-related materials (GRMs) for antibacterial applications while discussing their development, processing routes, mechanical properties, and antibacterial activity. Due to its suitable biological properties and processability, chitosan has been the most widely used biodegradable polymer for the fabrication of GRM-containing composites with antibacterial properties. The majority of biodegradable polymers (including cellulose-, gelatine-, PVA-, PCL-, and PHA-based polymers) exhibit little to no antibacterial effect alone; however, they show significant antibacterial activity (>70%) when combined with GRMs. In vitro and in vivo studies indicate that GRMs functionalization with biodegradable polymers also reduces potential GRM cytotoxicity. Overall, GRMs in biodegradable polymer matrices provide attractive antibacterial activity against a broad spectrum of bacteria (>30 different bacteria) along with improved mechanical properties over pristine polymers, where the type and the degree of improvement provided by GRMs depend on the specific matrix. For example, the addition of GRMs into chitosan, PVA, and PCL matrices increases their tensile strength by 80%, 180%, and 40%, respectively. Challenges remain in understanding the effects of processing routes and post-processing methods on the antibacterial activity and biocompatibility of biodegradable polymer/GRM composites. Given their promising properties and functionality, research on these composites is expected to further increase along with the implementation of new composite systems. These would include a wide range of applications, e.g., wound dressings, tissue engineering, drug delivery, biosensing, and photo-thermal therapy, as well as non-medical use, e.g., antibacterial food packaging, water treatment, and antibacterial fabrics. STATEMENT OF SIGNIFICANCE: Graphene-related materials (GRMs) in polymer matrices can provide excellent antibacterial activity against a broad spectrum of bacteria together with improved mechanical properties (e.g., tensile strength and elastic modulus) over pristine polymers; thus, research efforts and applications of biodegradable polymer matrix composites containing GRMs have increased notably in the last ten years. For the first time, the present review critically evaluates biodegradable polymer matrix composites containing GRMs for antibacterial applications while discussing their development, processing routes, mechanical properties, and antibacterial activity. Future research directions for each composite system are proposed to shed light on overcoming the existing challenges in composite performance (e.g., mechanical properties, toxicity) reported in the literature.
Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2022 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
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