Dividing attention during the Timed Up and Go enhances associations of several subtask performances with MCI and cognition.

Autor: Poole VN; Rush Alzheimer's Disease Research Center, Rush University Medical Center, Chicago, Illinois, United States of America.; Department of Orthopedic Surgery, Rush University Medical Center, Chicago, Illinois, United States of America., Dawe RJ; Rush Alzheimer's Disease Research Center, Rush University Medical Center, Chicago, Illinois, United States of America.; Department of Diagnostic Radiology and Nuclear Medicine, Rush University Medical Center, Chicago, Illinois, United States of America., Lamar M; Rush Alzheimer's Disease Research Center, Rush University Medical Center, Chicago, Illinois, United States of America.; Department of Psychiatry and Behavioral Sciences, Rush University Medical Center, Chicago, Illinois, United States of America., Esterman M; National Center for PTSD & Boston Attention and Learning Laboratory, VA Boston Healthcare System, Boston, Massachusetts, United States of America.; Department of Psychiatry, Boston University School of Medicine, Boston, Massachusetts, United States of America., Barnes L; Rush Alzheimer's Disease Research Center, Rush University Medical Center, Chicago, Illinois, United States of America.; Department of Psychiatry and Behavioral Sciences, Rush University Medical Center, Chicago, Illinois, United States of America.; Department of Neurological Sciences, Rush University Medical Center, Chicago, Illinois, United States of America., Leurgans SE; Rush Alzheimer's Disease Research Center, Rush University Medical Center, Chicago, Illinois, United States of America.; Department of Neurological Sciences, Rush University Medical Center, Chicago, Illinois, United States of America.; Department of Preventive Medicine, Rush University Medical Center, Chicago, Illinois, United States of America., Bennett DA; Rush Alzheimer's Disease Research Center, Rush University Medical Center, Chicago, Illinois, United States of America.; Department of Neurological Sciences, Rush University Medical Center, Chicago, Illinois, United States of America., Hausdorff JM; Rush Alzheimer's Disease Research Center, Rush University Medical Center, Chicago, Illinois, United States of America.; Department of Orthopedic Surgery, Rush University Medical Center, Chicago, Illinois, United States of America.; Center for the Study of Movement, Cognition, and Mobility, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel.; Sagol School of Neuroscience and Department of Physical Therapy, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel., Buchman AS; Rush Alzheimer's Disease Research Center, Rush University Medical Center, Chicago, Illinois, United States of America.; Department of Neurological Sciences, Rush University Medical Center, Chicago, Illinois, United States of America.
Jazyk: angličtina
Zdroj: PloS one [PLoS One] 2022 Aug 03; Vol. 17 (8), pp. e0269398. Date of Electronic Publication: 2022 Aug 03 (Print Publication: 2022).
DOI: 10.1371/journal.pone.0269398
Abstrakt: We tested the hypothesis that dividing attention would strengthen the ability to detect mild cognitive impairment (MCI) and specific cognitive abilities from Timed Up and Go (TUG) performance in the community setting. While wearing a belt-worn sensor, 757 dementia-free older adults completed TUG during two conditions, with and without a concurrent verbal serial subtraction task. We segmented TUG into its four subtasks (i.e., walking, turning, and two postural transitions), and extracted 18 measures that were summarized into nine validated sensor metrics. Participants also underwent a detailed cognitive assessment during the same visit. We then employed a series of regression models to determine the combinations of subtask sensor metrics most strongly associated with MCI and specific cognitive abilities for each condition. We also compared subtask performances with and without dividing attention to determine whether the costs of divided attention were associated with cognition. While slower TUG walking and turning were associated with higher odds of MCI under normal conditions, these and other subtask associations became more strongly linked to MCI when TUG was performed under divided attention. Walking and turns were also most strongly associated with executive function and attention, particularly under divided attention. These differential associations with cognition were mirrored by performance costs. However, since several TUG subtasks were more strongly associated with MCI and cognitive abilities when performed under divided attention, future work is needed to determine how instrumented dual-task TUG testing can more accurately estimate risk for late-life cognitive impairment in older adults.
Competing Interests: The authors have declared that no competing interests exist.
Databáze: MEDLINE
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