MicroRNAs: immune modulators in cancer immunotherapy.

Autor:	Xing Y; Shanghai Fifth People's Hospital and Key Laboratory of Medical Epigenetics and Metabolism, Institutes of Biomedical Sciences, Fudan University, Shanghai 200032, P.R. China., Wang Z; Department of Immunology, School of Basic Medical Sciences, Fudan University, Shanghai 200032, P.R. China., Lu Z; Department of Immunology, School of Basic Medical Sciences, Fudan University, Shanghai 200032, P.R. China.; Liver Cancer Institute, Zhongshan Hospital, Key Laboratory of Carcinogenesis and Cancer Invasion, Fudan University, Ministry of Education, Shanghai 200032, P.R. China., Xia J; Shanghai Fifth People's Hospital and Key Laboratory of Medical Epigenetics and Metabolism, Institutes of Biomedical Sciences, Fudan University, Shanghai 200032, P.R. China., Xie Z; Shanghai Fifth People's Hospital and Key Laboratory of Medical Epigenetics and Metabolism, Institutes of Biomedical Sciences, Fudan University, Shanghai 200032, P.R. China., Jiao M; Shanghai Fifth People's Hospital and Key Laboratory of Medical Epigenetics and Metabolism, Institutes of Biomedical Sciences, Fudan University, Shanghai 200032, P.R. China., Liu R; Shanghai Fifth People's Hospital and Key Laboratory of Medical Epigenetics and Metabolism, Institutes of Biomedical Sciences, Fudan University, Shanghai 200032, P.R. China., Chu Y; Shanghai Fifth People's Hospital and Key Laboratory of Medical Epigenetics and Metabolism, Institutes of Biomedical Sciences, Fudan University, Shanghai 200032, P.R. China.; Department of Immunology, School of Basic Medical Sciences, Fudan University, Shanghai 200032, P.R. China.
Jazyk:	angličtina
Zdroj:	Immunotherapy advances [Immunother Adv] 2021 May 13; Vol. 1 (1), pp. ltab006. Date of Electronic Publication: 2021 May 13 (Print Publication: 2021).
DOI:	10.1093/immadv/ltab006
Abstrakt:	MicroRNA (miRNA) is a class of endogenous small non-coding RNA of 18-25 nucleotides and plays regulatory roles in both physiological and pathological processes. Emerging evidence support that miRNAs function as immune modulators in tumors. MiRNAs as tumor suppressors or oncogenes are also found to be able to modulate anti-tumor immunity or link the crosstalk between tumor cells and immune cells surrounding. Based on the specific regulating function, miRNAs can be used as predictive, prognostic biomarkers, and therapeutic targets in immunotherapy. Here, we review new findings about the role of miRNAs in modulating immune responses, as well as discuss mechanisms underlying their dysregulation, and their clinical potentials as indicators of tumor prognosis or to sensitize cancer immunotherapy. (© The Author(s) 2021. Published by Oxford University Press on behalf of the British Society for Immunology.)
Databáze:	MEDLINE
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