Is netrin-1 a reliable inflammatory marker for periodontitis?

Autor:	Abdulfattah SY; Department of Oral Medicine, Periodontology, Diagnosis and Oral Radiology, Faculty of Dentistry, Mansoura University, Mansoura, Egypt., Baiomy AAB; Department of Clinical Pathology, Faculty of Medicine, Mansoura University, Mansoura, Egypt., Youssef JM; Department of Oral Medicine, Periodontology, Diagnosis and Oral Radiology, Faculty of Dentistry, Mansoura University, Mansoura, Egypt.
Jazyk:	angličtina
Zdroj:	Journal of advanced periodontology & implant dentistry [J Adv Periodontol Implant Dent] 2022 Jan 24; Vol. 14 (1), pp. 1-6. Date of Electronic Publication: 2022 Jan 24 (Print Publication: 2022).
DOI:	10.34172/japid.2022.001
Abstrakt:	Background: The current study tested netrin-1 as a reliable inflammatory marker of periodontal disease. Methods: Gingival crevicular fluid (GCF) samples were taken at baseline from 30 systemically healthy individuals. Fifteen subjects had stage II grade A or B periodontitis, and 15 were periodontally and clinically healthy. Whole-mouth periodontal parameters [probing depth (PD), clinical attachment loss (CAL), plaque index (PI), and gingival index (GI)] were recorded. The GCF samples were re-collected, and clinical parameters were re-recorded after six weeks following full-mouth scaling and root planing (SRP) in the periodontitis group. Results: Netrin-1 GCF levels were significantly lower in periodontitis patients than periodontally healthy individuals at baseline with a significant increase in netrin-1 GCF levels after SRP ( P <0.05). Conclusion: Netrin-1 may have a significant role in the inflammatory process of chronic periodontitis; thus, it could be a promising anti-inflammatory marker in periodontal disease. Competing Interests: The authors declare that they have no competing interest. (© 2022 The Author(s).)
Databáze:	MEDLINE
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