Impaired recollection and initially preserved familiarity in a patient with bilateral fornix transection following third ventricle colloid cyst removal: A two-year follow-up study.
| Autor: | Fuentes M; Department of Geriatrics and Day Centre, Geriatric Orthopaedic Surgery Centre, Caritas-Klinik Dominikus, Berlin-Reinickendorf, Berlin, Germany., Sales A; Department of Psychology, University of Valencia, Valencia, Spain., Charquero-Ballester M; School of Communication and Culture, Aarhus University, Aarhus, Denmark., García-Martí G; CIBER of Mental Health (CIBERSAM), Hospital Clínico Universitario de Valencia, Valencia, Spain.; Quirónsalud Hospital, Valencia, Spain., Meléndez JC; Department of Psychology, University of Valencia, Valencia, Spain., Espert R; Department of Psychology, University of Valencia, Valencia, Spain., Scheel M; Department of Neuroradiology, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany., Bauknecht HC; Department of Neuroradiology, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany., Simon K; Department of Geriatrics and Day Centre, Geriatric Orthopaedic Surgery Centre, Caritas-Klinik Dominikus, Berlin-Reinickendorf, Berlin, Germany., Köpstein U; Department of Geriatrics and Day Centre, Geriatric Orthopaedic Surgery Centre, Caritas-Klinik Dominikus, Berlin-Reinickendorf, Berlin, Germany., Gebauer S; Department of Geriatrics and Day Centre, Geriatric Orthopaedic Surgery Centre, Caritas-Klinik Dominikus, Berlin-Reinickendorf, Berlin, Germany., Algarabel S; Department of Psychology, University of Valencia, Valencia, Spain. |
|---|---|
| Jazyk: | angličtina |
| Zdroj: | Applied neuropsychology. Adult [Appl Neuropsychol Adult] 2024 Sep-Oct; Vol. 31 (5), pp. 994-1006. Date of Electronic Publication: 2022 Aug 02. |
| DOI: | 10.1080/23279095.2022.2104162 |
| Abstrakt: | Objective: Recognition memory is widely accepted as a dual process-based model, namely familiarity and recollection. However, the location of their specific neurobiological substrates remains unclear. Similar to hippocampal damage, fornix damage has been associated with recollection memory but not familiarity memory deficits. To understand the neural basis of recognition memory, determining the importance of the fornix and its hippocampal connections is essential. Methods: Recognition memory was examined in a 45-year-old male who underwent a complete bilateral fornix section following the removal of a third ventricle colloid cyst. The application of familiarity and recollection for recognition memory decisions was investigated via an immediate and delayed associative recognition test and an immediate and delayed forced-choice task in the patient and a control group ( N = 15) over a two-year follow-up period. Complete demographic, neuropsychological, neuropsychiatric, and neuroradiological characterizations of this patient were performed. Results: Persistent immediate and delayed verbal recollection memory deficits were observed in the patient. Moreover, delayed familiarity-based recognition memory declined gradually over the follow-up period, immediate familiarity-based recognition memory was unaffected, and reduced non-verbal memory improved. Conclusion: The present findings support models that the extended hippocampal system, including the fornices, does not appear to play a role in familiarity memory but is particularly important for recollection memory. Moreover, our study suggests that bilateral fornix transection may be associated with relatively functional recovery of non-verbal memory. |
| Databáze: | MEDLINE |
| Externí odkaz: |
|