| Autor: |
Ntamo Y; Biomedical Research and Innovation Platform, South African Medical Research Council, Tygerberg, South Africa., Jack B; Biomedical Research and Innovation Platform, South African Medical Research Council, Tygerberg, South Africa., Ziqubu K; Department of Biochemistry, North-West University, Mmabatho, South Africa., Mazibuko-Mbeje SE; Department of Biochemistry, North-West University, Mmabatho, South Africa., Nkambule BB; School of Laboratory Medicine and Medical Sciences, University of KwaZulu-Natal, Durban, South Africa., Nyambuya TM; Department of Health Sciences, Namibia University of Science and Technology, Windhoek, Namibia., Mabhida SE; Biomedical Research and Innovation Platform, South African Medical Research Council, Tygerberg, South Africa., Hanser S; Department of Physiology and Environmental Health, University of Limpopo, Sovenga, South Africa., Orlando P; Department of Life and Environmental Sciences, Polytechnic University of Marche, Ancona, Italy., Tiano L; Department of Life and Environmental Sciences, Polytechnic University of Marche, Ancona, Italy., Dludla PV; Biomedical Research and Innovation Platform, South African Medical Research Council, Tygerberg, South Africa.; Department of Biochemistry and Microbiology, University of Zululand, KwaDlangezwa, South Africa. |
| Abstrakt: |
Epigallocatechin gallate (EGCG) is one of the most abundant and powerful flavonoids contained in green tea. Because of the global increase in green tea consumption, there has been a general interest in understanding its health benefits, including its bioactive compounds like EGCG. Indeed, preclinical evidence already indicates that EGCG demonstrated a strong antioxidant and anti-inflammatory properties that could be essential in protecting against metabolic syndrome. The current review explores clinical evidence reporting on the beneficial effects of EGCG supplementation in obese subjects or patients with diverse metabolic complications that include type 2 diabetes and cardiovascular disease. The discussion incorporates the impact of different formulations of EGCG, as well as the effective doses and treatment duration. Importantly, besides highlighting the potential use of EGCG as a nutraceutical, the current review also discusses crucial evidence related to its pharmaceutical development as an agent to hinder metabolic diseases, including its bioavailability and metabolism profile, as well as its well-known biological properties. |
