Cyclopeptide Alkaloids from Discaria chacaye (Rhamnaceae) as Result of Symbiosis with Frankia (Actinomycetales).

Autor: Quiroz-Carreño S; Laboratorio de Síntesis y Biotransformación de Productos Naturales, Departamento Ciencias Básicas, Facultad de Ciencias, Universidad del Bio-Bio, Av. Andrés Bello N° 720, Casilla 447, CP 3780000, Chillán, Chile., Muñoz-Nuñez E; Laboratorio de Síntesis y Biotransformación de Productos Naturales, Departamento Ciencias Básicas, Facultad de Ciencias, Universidad del Bio-Bio, Av. Andrés Bello N° 720, Casilla 447, CP 3780000, Chillán, Chile., Silva FL; Instituto de Ciencias da Saúde, Universidade Paulista, Sao Paulo, Brazil., Devotto-Moreno L; Instituto de Investigaciones Agropecuarias, INIA Quilamapu, Chillán, Chile., Seigler DS; Department of Plant Biology, Herbarium, University of Illinois at Urbana-Champaign, Urbana-Champaign, Il, USA., Pastene-Navarrete E; Laboratorio de Síntesis y Biotransformación de Productos Naturales, Departamento Ciencias Básicas, Facultad de Ciencias, Universidad del Bio-Bio, Av. Andrés Bello N° 720, Casilla 447, CP 3780000, Chillán, Chile., Cespedes-Acuña CL; Laboratorio de Síntesis y Biotransformación de Productos Naturales, Departamento Ciencias Básicas, Facultad de Ciencias, Universidad del Bio-Bio, Av. Andrés Bello N° 720, Casilla 447, CP 3780000, Chillán, Chile., Alarcon-Enos J; Laboratorio de Síntesis y Biotransformación de Productos Naturales, Departamento Ciencias Básicas, Facultad de Ciencias, Universidad del Bio-Bio, Av. Andrés Bello N° 720, Casilla 447, CP 3780000, Chillán, Chile.
Jazyk: angličtina
Zdroj: Chemistry & biodiversity [Chem Biodivers] 2022 Sep; Vol. 19 (9), pp. e202200630. Date of Electronic Publication: 2022 Aug 17.
DOI: 10.1002/cbdv.202200630
Abstrakt: Cyclopeptide alkaloids with different biological activities are present in plants of the family Rhamnaceae. Plants of this family grow in a symbiotic relationship with aerobic Gram-positive actinomycetes belonging to the genus Frankia. This goal of this research was a study of the comparative profile of alkaloids present in Discaria chacaye and to establish a connection between the presence or absence of Frankia sp. and the alkaloids. In addition, insecticidal activities of the alkaloidal extract were examined. A total of 24 alkaloids were identified, of which 12 have a benzylisoquinoline skeleton, 9 were cyclopeptides, 2 isoquinolines, and 1 aporphine. The presence of cyclopeptide alkaloids is associated with Frankia nodules in the plant root. The alkaloid extracts showed insecticidal activity with mortality dose-dependence and LD 50 values between 44 to 71 μg/mL.
(© 2022 Wiley-VHCA AG, Zurich, Switzerland.)
Databáze: MEDLINE
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