Endometriosis and Systemic Lupus Erythematosus: Systematic Review and Meta-analysis.

Autor: Ferrari-Souza JP; Graduate Program in Biological Sciences, Biochemistry, Universidade Federal Do Rio Grande do Sul, RS, Porto Alegre, Brazil. joaopedroferrarisouza@gmail.com.; Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA, USA. joaopedroferrarisouza@gmail.com.; Medical School, Universidade Federal Do Rio Grande Do Sul, Porto Alegre, RS, Brazil. joaopedroferrarisouza@gmail.com., Pedrotti MT; Medical School, Universidade Federal Do Rio Grande Do Sul, Porto Alegre, RS, Brazil., Moretto EE; Medical School, Universidade Federal Do Rio Grande Do Sul, Porto Alegre, RS, Brazil., Farenzena LP; Medical School, Universidade Federal Do Rio Grande Do Sul, Porto Alegre, RS, Brazil., Crippa LG; Medical School, Universidade Federal Do Rio Grande Do Sul, Porto Alegre, RS, Brazil., Cunha-Filho JS; Department of Obstetrics-Gynecology, Universidade Federal Do Rio Grande Do Sul, Porto Alegre, RS, Brazil.
Jazyk: angličtina
Zdroj: Reproductive sciences (Thousand Oaks, Calif.) [Reprod Sci] 2023 Apr; Vol. 30 (4), pp. 997-1005. Date of Electronic Publication: 2022 Aug 01.
DOI: 10.1007/s43032-022-01045-3
Abstrakt: Endometriosis is a chronic gynaecological condition characterized by inflammatory and immune abnormalities. Likewise, these dysfunctions are important hallmarks of systemic lupus erythematosus (SLE), a condition that also has a high prevalence among women in reproductive age. Therefore, we conducted a systematic review and meta-analysis to investigate the association between endometriosis and SLE. We searched Medline and Web of Science for articles published from database inception to March 1, 2021. Random-effects meta-analysis was performed to provide a pooled risk ratio (RR). Individual study quality was evaluated following the National Heart, Lung, and Blood Institute Quality Assessment Tools (NHLBI QAT). From the 225 articles identified through our search, five studies-assessing 152,355 women-were included. Included studies presented an overall poor or fair quality rating. We observed a significant association between endometriosis and SLE (RR = 2.47, 95% confidence interval: 1.33-4.59, P < 0.004, I 2  = 54%). Sensitivity analyses stratifying articles by study design demonstrated that the association was significant in cross-sectional and case-control studies (RR = 5.07, 95% confidence interval: 1.42-18.11, P < 0.012), as well as in cohort studies (RR = 2.07, 95% confidence interval: 1.02-4.20, P < 0.044). In spite of the limited quality of included studies, our results suggest the existence of an association between endometriosis and SLE. These findings can aid medical assessment of patients with endometriosis, as well as provide further insights to better understand this gynaecological disorder.
(© 2022. The Author(s), under exclusive licence to Society for Reproductive Investigation.)
Databáze: MEDLINE
Externí odkaz: