Microstructural alterations measured by diffusion tensor imaging following transcatheter aortic valve replacement and their association with cerebral ischemic injury and cognitive function - a prospective study.

Autor: Varga A; Department of Diagnostic Radiology, Heart and Vascular Centre, Semmelweis University, Budapest, Hungary. varga.andrea.bandi@gmail.com.; Department of Interventional Radiology, Heart and Vascular Centre, Semmelweis University, Budapest, Hungary. varga.andrea.bandi@gmail.com., Gyebnár G; Medical Imaging Centre, Semmelweis University, Budapest, Hungary., Suhai FI; Department of Diagnostic Radiology, Heart and Vascular Centre, Semmelweis University, Budapest, Hungary., Nagy AI; Department of Cardiology, Heart and Vascular Centre, Semmelweis University, Budapest, Hungary., Kozák LR; Medical Imaging Centre, Semmelweis University, Budapest, Hungary., Póka CÁ; Medical Imaging Centre, Semmelweis University, Budapest, Hungary., Turáni MF; Department of Cardiology, Medical Centre - Hungarian Defence Forces, Budapest, Hungary., Borzsák S; Department of Diagnostic Radiology, Heart and Vascular Centre, Semmelweis University, Budapest, Hungary., Apor A; Department of Cardiology, Heart and Vascular Centre, Semmelweis University, Budapest, Hungary., Bartykowszki A; Department of Cardiology, Heart and Vascular Centre, Semmelweis University, Budapest, Hungary.; MTA-SE Cardiovascular Imaging Research Group, Heart and Vascular Centre, Semmelweis University, Budapest, Hungary., Szilveszter B; Department of Cardiology, Heart and Vascular Centre, Semmelweis University, Budapest, Hungary.; MTA-SE Cardiovascular Imaging Research Group, Heart and Vascular Centre, Semmelweis University, Budapest, Hungary., Kolossváry M; MTA-SE Cardiovascular Imaging Research Group, Heart and Vascular Centre, Semmelweis University, Budapest, Hungary., Maurovich-Horvat P; Medical Imaging Centre, Semmelweis University, Budapest, Hungary.; MTA-SE Cardiovascular Imaging Research Group, Heart and Vascular Centre, Semmelweis University, Budapest, Hungary., Merkely B; Department of Cardiology, Heart and Vascular Centre, Semmelweis University, Budapest, Hungary.
Jazyk: angličtina
Zdroj: Neuroradiology [Neuroradiology] 2022 Dec; Vol. 64 (12), pp. 2343-2356. Date of Electronic Publication: 2022 Aug 01.
DOI: 10.1007/s00234-022-03017-5
Abstrakt: Purpose: We assessed diffusion tensor imaging (DTI) metric changes of the corpus callosum and cingulum correlated to postprocedural ischemic lesion load (ILL) and cognitive performance in transcatheter aortic valve replacement (TAVR).
Methods: TAVR subjects had DTI post-TAVR (≤ 8 days) and at 6 months (78 participants, males 56%, age 78.8 years ± 6.3) and four neurocognitive tests (pre-TAVR, post-TAVR, 6 months, 1 year). DTI metrics (fractional anisotropy (FA), mean diffusivity (MD), axial diffusivity (AD), radial diffusivity (RD)) were calculated for 7 regions: corpus callosum (genu, body, splenium) and cingulum (cingulate gyrus, parahippocampal cingulum bilaterally). DTI metrics post-TAVR and at 6 months were compared with Student's t-test (p < 0.0071) and ANOVA covarying for sex, ILL (p < 0.05) with post hoc analysis of ILL groups (p < 0.0167). Repeated-measures linear mixed-effect model (p < 0.05) was performed to investigate the effect of time and ILL on cognition.
Results: At 6 months, significant decrease of the following DTI metrics was detected: AD (genu, body, splenium, right parahippocampal cingulum: p ≤ 0.0046); MD (body, both cingulate gyri: p ≤ 0.0050); RD (left cingulate gyrus: p = 0.0021); FA (splenium: p < 0.0001). ANOVA confirmed significant effect of female sex on AD + MD reduction (body, right cingulate gyrus) and AD reduction (left cingulate gyrus) (p ≤ 0.0254). Significant negative effect of ILL on some DTI metric changes was found (AD + MD-body: p ≤ 0.0050; MD-left cingulate gyrus: p = 0.0087). Cognitive performance remained stable with significant negative correlation of ILL and retrograde memory and visual scores (p ≤ 0.0483).
Conclusion: Significant effect of TAVR on cerebral microstructural integrity was found with reduced diffusivities opposite to the trends reported in various neurodegenerative conditions/ageing, notably in women and lower ILL, and with preserved/improved cognition.
Trial Registration Number: NCT02826200 at ClinicalTrials.gov; date of registration: 07. July 2016.
(© 2022. The Author(s).)
Databáze: MEDLINE
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