Prognostic utility of SOX2, STAT3, and CD44 high /CD24 low expression in penile cancer.

Autor: de Barros FD; Hospital de Câncer de Pernambuco, Av Cruz Cabuga 1597 Santo Amaro, Recife, Pernambuco, 50040000, Brazil. felipedubourcq@outlook.com., Torres LC; Instituto de Medicina Integrada de Pernambuco, Recife, Pernambuco, Brazil., Araujo C; Faculdade de Medicina de Olinda, Olinda, Pernambuco, Brazil., da Silva Marinho F; Hospital de Câncer de Pernambuco, Av Cruz Cabuga 1597 Santo Amaro, Recife, Pernambuco, 50040000, Brazil., Dubourcq BC; Hospital de Câncer de Pernambuco, Av Cruz Cabuga 1597 Santo Amaro, Recife, Pernambuco, 50040000, Brazil., Dubourcq LC; Hospital de Câncer de Pernambuco, Av Cruz Cabuga 1597 Santo Amaro, Recife, Pernambuco, 50040000, Brazil., Guimarães GC; AC Camargo Cancer Center, São Paulo, Brazil.
Jazyk: angličtina
Zdroj: Journal of cancer research and clinical oncology [J Cancer Res Clin Oncol] 2023 May; Vol. 149 (5), pp. 2081-2094. Date of Electronic Publication: 2022 Aug 01.
DOI: 10.1007/s00432-022-04222-8
Abstrakt: Purpose: Penile cancer has a high incidence in developing countries. The standard treatment is removal of the primary tumor and, when necessary, inguinal lymphadenectomy. Currently, the most important prognostic factor is lymph node disease, however, the available staging methods are inaccurate, and the high morbidity rate of lymphadenectomy has stimulated the study of predictive biomarkers of lymph node metastasis for selecting the patients who need lymphadenectomy. SOX2, STAT3 and CD44 high /CD24 low were chosen because they have provided good predictive results in other squamous cell carcinoma (SCC), although there are no studies for penile cancer. Thus, the expression of SOX2, STAT3, CD24+, and CD44+ in the penile cancer tumor microenvironment was investigated for correlation with tumor behavior in SCC.
Methods: This observational, prospective, translational study included 34 men and investigated the expression of SOX2, STAT3, CD24+, and CD44+ in tumor tissue by flow cytometry.
Results: The median age of the 38 evaluated patients with penile cancer was 61 (37-80) years. Most patients presented a tumor located on the glans penis (82.3%), with the usual histological type (79.4%) and 61.7% of patients presented stage pT2. No metastasis was found in 85.3% of patients. The expression of SOX2, STAT3 and CD44 high /CD24 low in the microenvironment of penile SCC treated with lymphadenectomy was significantly associated with aggressive tumor behavior (p < 0.05). STAT3 expression shows discrepant points when evaluated in context of angiolymphatic vascular invasion.
Conclusion: SOX2, STAT3 and CD44 high /CD24 low in penile SCC can be indicators of prognosis, allowing for selection of more aggressive treatment when necessary.
(© 2022. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.)
Databáze: MEDLINE
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