Fat mass to fat-free mass ratio and its associations with clinical characteristics in asthma.
| Autor: | Rugila DF; Postgraduate Program in Rehabilitation Sciences, Pitágoras-Unopar University (UNOPAR), Londrina, Paraná, Brazil; Department of Physical Therapy, Laboratory of Research in Respiratory Physiotherapy (LFIP), State University of Londrina (UEL), Londrina, Paraná, Brazil., Oliveira JM; Postgraduate Program in Rehabilitation Sciences, Pitágoras-Unopar University (UNOPAR), Londrina, Paraná, Brazil; Department of Physical Therapy, Laboratory of Research in Respiratory Physiotherapy (LFIP), State University of Londrina (UEL), Londrina, Paraná, Brazil., Machado FVC; Department of Physical Therapy, Laboratory of Research in Respiratory Physiotherapy (LFIP), State University of Londrina (UEL), Londrina, Paraná, Brazil; Department of Research and Development, CIRO+, Horn, The Netherlands; NUTRIM School of Nutrition and Translational Research in Metabolism, Faculty of Health, Medicine and Life Sciences, Maastricht University, Maastricht, The Netherlands; Department of Respiratory Medicine, Maastricht University Medical Center (MUMC+), Maastricht, The Netherlands., Correia NS; Postgraduate Program in Rehabilitation Sciences, Pitágoras-Unopar University (UNOPAR), Londrina, Paraná, Brazil; Department of Physical Therapy, Laboratory of Research in Respiratory Physiotherapy (LFIP), State University of Londrina (UEL), Londrina, Paraná, Brazil., Puzzi VC; Postgraduate Program in Rehabilitation Sciences, Pitágoras-Unopar University (UNOPAR), Londrina, Paraná, Brazil; Department of Physical Therapy, Laboratory of Research in Respiratory Physiotherapy (LFIP), State University of Londrina (UEL), Londrina, Paraná, Brazil., Passos NFP; Department of Physical Therapy, School of Medicine, University of Sao Paulo (USP), Sao Paulo, Brazil., Freitas PD; Department of Physical Therapy, School of Medicine, University of Sao Paulo (USP), Sao Paulo, Brazil., Pitta F; Department of Physical Therapy, Laboratory of Research in Respiratory Physiotherapy (LFIP), State University of Londrina (UEL), Londrina, Paraná, Brazil., Carvalho CRF; Department of Physical Therapy, School of Medicine, University of Sao Paulo (USP), Sao Paulo, Brazil., Furlanetto KC; Postgraduate Program in Rehabilitation Sciences, Pitágoras-Unopar University (UNOPAR), Londrina, Paraná, Brazil; Department of Physical Therapy, Laboratory of Research in Respiratory Physiotherapy (LFIP), State University of Londrina (UEL), Londrina, Paraná, Brazil. Electronic address: karinafurlanetto@uel.br. |
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| Jazyk: | angličtina |
| Zdroj: | Heart & lung : the journal of critical care [Heart Lung] 2022 Nov-Dec; Vol. 56, pp. 154-160. Date of Electronic Publication: 2022 Jul 28. |
| DOI: | 10.1016/j.hrtlng.2022.07.006 |
| Abstrakt: | Background: Fat mass to fat-free mass ratio (FM/FFM) assesses the combined effect of the balance between fat mass and fat-free mass. Aims: to evaluate the associations beetween FM/FFM and clinical outcomes in asthma and to compare clinical characteristics between individuals with higher and lower FM/FFM. Methods: 128 participants with asthma underwent anthropometric, spirometry and bioelectrical impedance assessments. Physical activity in daily life (PADL) was assessed by the Actigraph for 7 days. Daily dose of inhaled medication, steps of pharmacological treatment, Asthma Control Questionnaire, Asthma Quality of Life Questionnaire and Hospital Anxiety and Depression Scale were also assessed. Participants were classified into two groups according to the 50th percentile of reference values for FM/FFM. Results: Individuals with higher FM/FFM (n=75) used higher daily doses of inhaled corticosteroids, had worse lung function and fewer steps/day when compared to those with lower FM/FFM (n=53) (P≤0.021). Associations were found between absolute values of FM/FFM with lung function (FEV Conclusion: Higher FM/FFM is significantly associated with worse clinical characteristics in individuals with asthma, such as higher doses of inhaled corticosteroids, worse lung function and fewer steps/day. Moreover, higher FM/FFM is a determining factor of physical inactivity and the highest steps of pharmacological treatment for asthma. Competing Interests: Conflict of Interest All authors have no conflict of interest to disclose. (Copyright © 2022 Elsevier Inc. All rights reserved.) |
| Databáze: | MEDLINE |
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