Generation of pro-and anti-inflammatory mediators after acetaminophen overdose in surviving and non-surviving patients.

Autor: Woolbright BL; Department of Pharmacology, Toxicology & Therapeutics, USA., Nguyen NT; Department of Pharmacology, Toxicology & Therapeutics, USA., McGill MR; Department of Pharmacology, Toxicology & Therapeutics, USA., Sharpe MR; Department of Internal Medicine, Division of Pulmonary, Critical Care and Sleep Medicine, University of Kansas Medical Center, Kansas City, Kansas, USA., Curry SC; Department of Medical Toxicology, Banner Good Samaritan Medical Center, Phoenix, AZ, USA; Department of Medicine, and Center for Toxicology and Pharmacology Education and Research, University of Arizona College of Medicine, Phoenix, AZ, USA., Jaeschke H; Department of Pharmacology, Toxicology & Therapeutics, USA. Electronic address: hjaeschke@kumc.edu.
Jazyk: angličtina
Zdroj: Toxicology letters [Toxicol Lett] 2022 Aug 15; Vol. 367, pp. 59-66. Date of Electronic Publication: 2022 Jul 26.
DOI: 10.1016/j.toxlet.2022.07.813
Abstrakt: Acetaminophen (APAP) overdose causes liver injury in animals and humans. Although well-studied in animals, limited longitudinal data exist on cytokine release after APAP overdose in patients. The purpose of this study was to quantify concentrations of cytokines in APAP overdose patients to determine if early cytokine or complement measurements can distinguish between surviving and non-surviving patients. Plasma was obtained from healthy controls, APAP overdose patients with no increase in liver transaminases, and surviving and non-surviving APAP overdose patients with severe liver injury. Interleukin-10 (IL-10), and CC chemokine ligand-2 (CCL2, MCP-1) were substantially elevated in surviving and non-surviving patients, whereas IL-6 and CXC chemokine ligand-8 (CXCL8, IL-8) had early elevations in a subset of patients only with liver injury. Day 1 IL-10 and IL-6 levels, and Day 2 CCL2, levels correlated positively with survival. There was no significant increase in IL-1α, IL-1β or TNF-α in any patient during the first week after APAP. Monitoring cytokines such as CCL2 may be a good indicator of patient prognosis; furthermore, these data indicate the inflammatory response after APAP overdose in patients is not mediated by a second phase of inflammation driven by the inflammasome.
(Copyright © 2022 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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