National Brazilian survey on the outcomes of hepatitis c retreatment in patients non-responders to direct antiviral agents.

Autor:	Ferraz MLG; Universidade Federal de São Paulo, Disciplina de Gastroenterologia, São Paulo, SP, Brazil. Electronic address: marialucia.ferraz@uol.com.br., Piccoli LZ; Serviço Municipal de Infectologia de Caxias do Sul, Caxias do Sul, RS, Brazil., Rezende R; Secretária Municipal de Saúde de Ribeirão Preto, Centro de Referência em Especialidades, Ribeirão Preto, SP, Brazil; Universidade São Paulo, Hospital das Clínicas da Faculdade de Medicina de Ribeirão Preto, Ribeirão Preto, SP, Brazil., Borba LA; Prefeitura Municipal de Criciúma, Ambulatório de Hepatites Virais, Criciúma, SC, Brazil., Junior AP; Hospital Nossa Senhora das Graças, Curitiba, PR, Brazil., Cheinquer H; Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil., Silva GF; Universidade Estadual Paulista Júlio de Mesquita Filho, Faculdade de Medicina de Botucatu, Botucatu, SP, Brazil., Ferreira PRA; Universidade Federal de São Paulo, Disciplina de Infectologia, São Paulo, SP, Brazil., Villela-Nogueira CA; Universidade Federal do Rio de Janeiro, Faculdade de Medicina, Rio de Janeiro, RJ, Brazil., Mazo DF; Universidade Estadual de Campinas, Faculdade de Ciências Médicas, Divisão de Gastroenterologia do Departamento de Clínica Médica, Campinas, SP, Brazil; Universidade de São Paulo, Faculdade de Medicina, Hospital das Clínicas, Divisão de Gastroenterologia e Hepatologia, São Paulo, SP, Brazil., Souza FF; Universidade São Paulo, Hospital das Clínicas da Faculdade de Medicina de Ribeirão Preto, Ribeirão Preto, SP, Brazil., Codes L; Hospital Português, Salvador, BA, Brazil; Escola Bahiana de Medicina e Saúde Pública, Salvador, BA, Brazil., Ivantes CAP; Secretaria Municipal de Saúde, Prefeitura de Curitiba, Curitiba, PR, Brazil., Gomide GPM; Universidade Federal do Triângulo Mineiro, Uberaba, MG, Brazil., Pereira GHS; Hospital Federal de Bonsucesso (Ministério da Saúde), Serviço de Gastroenterologia e Hepatologia, Rio de Janeiro, RJ, Brazil., Pessôa MG; Universidade de São Paulo, Faculdade de Medicina, São Paulo, SP, Brazil., França AVC; Universidade Federal de Sergipe, São Cristóvão, SE, Brazil., Pinto ADS; Fundação de Medicina Tropical do Amazonas, Programa de Pós-graduação em Medicina Tropical, Manaus, AM, Brazil., Teixeira R; Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil., Bittencourt PL; Hospital Português, Salvador, BA, Brazil; Escola Bahiana de Medicina e Saúde Pública, Salvador, BA, Brazil.
Jazyk:	angličtina
Zdroj:	The Brazilian journal of infectious diseases : an official publication of the Brazilian Society of Infectious Diseases [Braz J Infect Dis] 2022 Jul-Aug; Vol. 26 (4), pp. 102388. Date of Electronic Publication: 2022 Jul 26.
DOI:	10.1016/j.bjid.2022.102388
Abstrakt:	Background and Aims: Treatment of hepatitis C with direct antiviral agents (DAA) is associated with almost 95% of sustained virological response. However, some patients need retreatment. In Brazil, it should be done according to the Ministry of Health guidelines, frequently updated to include newly available drugs. This study aimed to conduct a national survey about the characteristics and outcomes of retreatment of hepatitis C in previously non-responders to DAAs. Patients and Methods: Institutions from all over the country were invited to participate in a national registry for retreatment, including information about clinical and epidemiological characteristics of the patients, type and outcomes of retreatment regimens. Only patients previously treated with interferon-free regimens were included. Results: As previous treatments the distribution was: SOF/DCV (56%), SOF/SIM (22%), 3D (11%), SOF/LED (6%) and SOF/RBV (5%). For retreatment the most frequently used drugs were SOF/GP (46%), SOF/DCV (23%) and SOF/VEL (11%). From 159 patients retreated, 132/159 (83%) had complete information in the registry and among them only seven patients were non-responders (SVR of 94.6%). All retreatments were well tolerated, without any serious adverse events or interruptions. Conclusion: The retreatment of patients previously non-responders to DAAs was associated with high rate of SVR in this sample of Brazilian patients. This finding allows us to conclude that the retreatment options available in the public health system in Brazil are effective and safe and are an important component of the strategy of elimination of hepatitis C in our country. Competing Interests: Conflicts of interest The authors declare no conflicts of interest. (Copyright © 2022 Sociedade Brasileira de Infectologia. Published by Elsevier España, S.L.U. All rights reserved.)
Databáze:	MEDLINE
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